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STUDIES OF THE NATURAL HISTORY AND TREATMENT OF DUCK HEPATITIS B VIRUS INFECTION

STUDIES OF THE NATURAL HISTORY AND TREATMENT OF DUCK HEPATITIS B VIRUS INFECTION
鸭乙型肝炎病毒感染自然史及治疗的研究
批准号：
3897716
负责人：
E A JONES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3897716
关键词：
antiviral agents disease /disorder model disease carrier state drug screening /evaluation duck hepatitis B virus ducks hepatitis B immunomodulators liver disorder chemotherapy virus replication

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中文摘要
翻译
人类在结构和性质上有许多相似之处
英文摘要
There are many similarities in structure and properties between the human hepatitis B virus (HEV) and the duck hepatitis B virus (DHBV). These similarities suggest that DHBV infection in ducks may be a useful experimental model of human HBV infection, particularly as HBV cannot be grown readily in cell culture. Ducks infected with DHBV at birth become chronic carriers of the virus, although they may not develop overt hepatitis. Some DHBV-infected ducks have been reported to develop hepatocellular carcinoma. The analogous human tumor is strongly linked etiologically with chronic hepatitis B infection. As a screening test for new effective therapies for chronic type B hepatitis in man, new antiviral and immunomodulatory agents are being assessed for their ability to suppress DHBV replication in ducks.
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