IMMUNOLOGICAL STUDIES IN CHRONIC VIRAL HEPATITIS

慢性病毒性肝炎的免疫学研究

• 批准号: 3918254
• 负责人: E A JONES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918254
• 关键词: antiviral agents; cellular immunity; chronic disease /disorder; hepatitis A; hepatitis B; hepatitis B virus group; human subject; immunosuppressive; immunotherapy; liver disorder chemotherapy; tissue /cell culture

Immunological factors seem to be important in determining the course and outcome of both acute and chronic viral hepatitis. Furthermore, promising therapies for chronic viral hepatitis have profound effects on immune function and sustained responses to therapy may depend largely on restoration of normal immune responsiveness. The role of immunologic mechanisms in determining the course and ultimate outcome of viral hepatitis is being studied and the effects of therapies on the immune system are being evaluated. Serial studies of cellular immune function have been conducted on patients with chronic type B hepatitis. In addition, the immunological status of patients with chronic type B hepatitis is being assessed in detail and the effects of immunosuppressive as well as antiviral therapy on immunological function in these patients are being studied prospectively.

免疫学因素似乎在决定 急性和慢性病毒性肝炎的病程和转归。 此外，有希望的慢性病毒性肝炎治疗方法， 对免疫功能和持续反应的深刻影响， 治疗可能在很大程度上取决于正常免疫功能的恢复。 响应能力。 免疫机制在决定 正在研究病毒性肝炎的病程和最终结果 治疗对免疫系统的影响 评估。 细胞免疫功能的系列研究已经 对慢性B型肝炎患者进行了研究。 此外，本发明还提供了一种方法， 慢性B型肝炎患者的免疫状态 正在进行详细评估，免疫抑制剂的作用 以及抗病毒治疗对免疫功能的影响， 正在对患者进行前瞻性研究。