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TRIALS OF THERAPIES FOR PRIMARY BILLIARY CIRRHOSIS

TRIALS OF THERAPIES FOR PRIMARY BILLIARY CIRRHOSIS
原发性胆汁性肝硬化的治疗试验
批准号：
3876440
负责人：
E A JONES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3876440
关键词：
adult human (21+) autoimmune disorder biliary tract disorder biliary tract disorder chemotherapy bilirubin biopsy chlorambucil dosage drug adverse effect histopathology human subject human therapy evaluation immunoglobulin M immunosuppressive liver cirrhosis longitudinal human study methotrexate orphan disease /drug serology /serodiagnosis

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中文摘要
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英文摘要
Primary binary cirrhosis (PBC) is a disease of unknown etiology characterized by slowly progressive intrahepatic cholestasis due to non-suppurative, destruction of small intrahepatic bile ducts. Because some other autoimmune diseases appear to respond favorably to certain immunosuppressive agents, trials of selected immunosuppressive drugs are being undertaken in patients with symptomatic PBC. In a randomized controlled trial of chlorambucil therapy, treatment with the drug was associated with a decrease in the rate of increase of serum bilirubin, normalization of elevated serum IgM levels and an improvement in inflammatory cell infiltration in liver biopsies. These findings have prompted a search for safer and more effective immunosuppressive drugs with less carcinogenic potential than chlorambucol. Ten patients with PBC have been entered into an open trial of methotrexate therapy and are tolerating the drug well.
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STUDIES OF THE OPIATE SYSTEM IN CHOLESTATIC LIVER DISEASE
CONTROLLED TRIAL OF CHLORAMBUCIL THERAPY IN PRIMARY BILIARY CIRRHOSIS
NATURAL HISTORY AND TREATMENT OF CHRONIC NON-A, NON-B HEPATITIS
STUDIES OF THE NATURAL HISTORY AND TREATMENT OF CHRONIC TYPE B HEPATITIS
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