COGNITIVE NEUROPHYSIOLOGIC SIGNS OF COCAINE ABSTINENCE

可卡因戒断的认知神经生理学迹象

• 批准号: 3853851
• 负责人: R I HERNING
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853851
• 关键词: cocaine; cognition disorders; drug abuse therapy; drug addiction; drug withdrawal; human subject; memory disorders; neural information processing; neuropsychological tests; questionnaires; sleep disorders

Cognitive impairments and sleep disruption have been reported in patients withdrawing from cocaine. The nature of these disorders have yet to be documented in clinical laboratory studies. The present study evaluates cognitive information processing in subjects on a clinical ward withdrawing from cocaine with a battery of tasks (auditory rare event monitoring, two continuous performance tasks, four Sternburg memory tests). Sleep quality and duration is monitored by a subjective questionnaire. Fourteen subjects including controls have been tested in this study over a 6 to 8 week withdrawal period. Stimulus evaluation and memory deficits were observed in the cocaine addicts. Clarification of the nature of the cognitive deficits and of sleep loss will lead to more effective treatment strategies for cocaine withdrawal.

据报道， 戒掉可卡因 这些疾病的本质还有待于 在临床实验室研究中记录。 本研究评价 临床病房受试者的认知信息加工 用一系列任务（听觉罕见事件）戒断可卡因 监控、两个连续性能任务、四个Sternburg内存 测试）。 睡眠质量和持续时间由主观监测 问卷 包括对照组在内的14名受试者已在 本研究的停药期为6至8周。 刺激评价和 在可卡因成瘾者中观察到记忆缺陷。 澄清认知缺陷和睡眠不足的性质 将导致更有效的可卡因戒断治疗策略。