MAPPING THE EFFECTS OF COCAINE

绘制可卡因的影响图

• 批准号: 3853834
• 负责人: R I HERNING
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853834
• 关键词: brain mapping; cocaine; electroencephalography; euphoria; frontal lobe /cortex; human subject; positron emission tomography

The effects of cocaine on scalp EEG and FDG PET scans are being compared to determine the brain areas involved in the cocaine-induced euphoria. In previous studies, cocaine increased EEG beta power. The distribution of cortical areas responsible for the EEG beta increase and the time course of the beta increase have not as yet been determined. The present study was designed to answer these two questions. The complimentary nature of the EEG and PET data will delineate the anatomical and electrophysiologic mechanisms involved in cocaine induced euphoria. Twenty subjects were tested using EEG measures with placebo, 20mg and 40mg of cocaine in double blind order in previous years and seven additional subjects were tested during the current year. EEG beta increased in dose dependent manner starting immediately after the injection and continuing for twenty minutes. The increase in EEG beta was maximal in frontal cortical areas. The relationship between the increase in beta and subjective state is currently being investigated.

可卡因对头皮EEG和FDG PET扫描的影响正在进行比较 来确定可卡因引起的欣快感所涉及的大脑区域 在以前的研究中，可卡因增加了EEG β功率。 分布 负责脑电图β增加的皮层区域， 贝塔系数的上升幅度尚未确定。 本 研究旨在回答这两个问题。 EEG和PET数据的互补性将描绘出 可卡因诱导的神经细胞凋亡的解剖学和电生理学机制 欣快症 20名受试者使用安慰剂、20 mg和 40毫克可卡因在双盲顺序在前几年和七 本年度还对其他科目进行了测试。 脑电图β 在给药后立即开始以剂量依赖性方式增加 注射并持续20分钟。 脑电图β的增加 在额叶皮质区最大。 的关系 目前正在研究β和主观状态的增加。