MAPPING THE EFFECTS OF COCAINE

可卡因对头皮脑电和FDG正电子发射计算机断层扫描的影响正在进行比较 以确定与可卡因引起的快感有关的大脑区域。 在之前的研究中，可卡因增加了脑电的β能力。分布情况 负责脑电β值增加的皮质区域和时间 到目前为止，Beta增加的过程尚未确定。现在 这项研究就是为了回答这两个问题。 EEG和PET数据的互补性将勾勒出 可卡因诱导的解剖和电生理机制 欣快感。 对20名受试者进行了脑电测试，其中安慰剂、20毫克和 40毫克可卡因在前几年和七年中按双盲顺序 在本年度还测试了更多的受试者。脑电测试版 以剂量依赖的方式增加，从紧接在 注射，持续20分钟。脑电β值的增加 额叶皮质区最大。两国之间的关系 目前正在调查Beta和主观状态的增加。

The effects of cocaine on scalp EEG and FDG PET scans are being compared to determine the brain areas involved in the cocaine-induced euphoria. In previous studies, cocaine increased EEG beta power. The distribution of cortical areas responsible for the EEG beta increase and the time course of the beta increase have not as yet been determined. The present study was designed to answer these two questions. The complimentary nature of the EEG and PET data will delineate the anatomical and electrophysiologic mechanisms involved in cocaine induced euphoria. Twenty subjects were tested using EEG measures with placebo, 20mg and 40mg of cocaine in double blind order in previous years and seven additional subjects were tested during the current year. EEG beta increased in dose dependent manner starting immediately after the injection and continuing for twenty minutes. The increase in EEG beta was maximal in frontal cortical areas. The relationship between the increase in beta and subjective state is currently being investigated.