MAPPING THE EFFECTS OF OPIOID AGONISTS BY EEG

比较吗啡对头皮EEG和FDG PET扫描的影响 以确定在欣快感中调用的大脑区域。病原学收集于 目前正在分析20个头皮部位的脑电数据，这些数据来自 吸毒者接受安慰剂、15毫克和30毫克吗啡注射。 这些受试者随后在接受FDG PET扫描的同时 安慰剂和30毫克的吗啡。正电子发射计算机断层扫描由我们的 合作者。EEG数据本身就提供了对时间进程的洞察 MU激动剂在人体和大脑皮层的电生理效应 亩效应的分布。宠物技术本身并不能提供 有关Mu效果的时间进程的信息。在预赛中 分析显示，12名受试者的脑电增量和theta功率均增加。 从15分钟开始，一直持续到45分钟后 肌肉注射。文物检测的变化正在发生 研究表明，这些脑电变化与 可以调查吗啡的主观影响。

Effects of morphine on the scalp EEG and FDG PET scans are being compared to determine the brain areas invoked in euphoria. Etiology collected in past years and is now analyzing the EEG data from 20 scalp locations from post addicts receiving placebo, 15 and 30 mg injections of morphine. These subjects subsequently received FDG PET scans while receiving placebo and 30 mg of morphine. The PET scans are performed by our collaborators. The EEG data by itself provides insight into time course of electrophysiologic effects of a mu agonist in humans and the cortical distribution of mu effects. PET techniques do not by themselves provide information about the time course of the mu effects. In the preliminary analysis, twelve subjects had increased EEG delta and the theta power beginning 15 minutes and persisting until 45 minutes after the intramuscular injection. Changes in artifact detection were being investigated so that the relationship between these EEG changes and subjective effects of morphine can be investigated.