COGNITIVE NEUROPHYSIOLOGIC SIGNS OF COCAINE ABSTINENCE

可卡因戒断的认知神经生理学迹象

• 批准号: 3838761
• 负责人: R I HERNING
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838761
• 关键词: cocaine; cognition disorders; drug abuse therapy; drug addiction; drug withdrawal; electroencephalography; human subject; interview; memory disorders; neural information processing; neurophysiology; neuropsychological tests

Neurophysiologic and cognitive impairments have been reported in cocaine dependent patients abstaining from cocaine. The nature of these impairments have yet to be documented in a controlled clinical laboratory study. The present study monitors the subjective, psychiatric, cognitive and neurophysiologic status of cocaine dependent patient and the matched control subjects over a six to eight week period of abstinence. The control group is similar to the cocaine dependent patients in age, education and drug use history other than cocaine. The control group also controls for the effects of hospitalization and practice on the cognitive tasks. The EEG and cognitive information processing brain potentials were recorded from Fz, Cz, Pz, F3, F4, P3, P4, T3, T4, 01 and 02 scalp sites during three passive (Eyes Closed, Eyes open and Brainstem Auditory Evoked Response procedures) and seven active behavioral tasks (Auditory Rare event Monitoring Task, two Continuous Performance Tasks and four Sternberg Memory Tasks). Fourteen of the planned twenty subjects were tested in the previous year. Statistical analysis was performed in the current year. The amount and distribution of EEG beta (fast brain activity) in the cocaine dependent patients was significantly different than the control subject over the entire study. This EEG pattern may represent residual neurological alterations in cocaine dependent patients and may be a factor contributing to treatment relapse. The P300 brain component of the cocaine dependent subjects was reduced on the a visual and auditory cognitive task. Percent correct was on the Sternberg memory task was progressively poorer for the cocaine dependent individuals over the two month period of abstinence. Thus, the efficacy of treatment interventions for cocaine dependence my now be monitored by objective neurophysiological and performance measures.

据报道，可卡因会导致神经生理和认知障碍 依赖可卡因的病人 百货公司是些 在受控的临床实验室中， study. 本研究监测的主观，精神，认知 可卡因依赖患者及其匹配者的神经生理状态 对照组在六到八周的禁欲期内。 的 对照组与可卡因依赖患者年龄相仿， 除了可卡因以外的其他毒品使用史。 对照组也 控制住院和实践对认知功能的影响 任务 脑电图和认知信息处理脑电位 从Fz、Cz、Pz、F3、F4、P3、P4、T3、T4、01和02头皮部位记录 在三个被动（闭眼，睁眼和脑干听觉诱发） 反应程序）和七个主动行为任务（听觉罕见事件 监控任务、两个连续执行任务和四个斯滕贝格记忆任务 任务）。 计划的20名受试者中有14名在 上年 本年度进行了统计分析。 脑电β波（快速脑活动）的数量和分布， 可卡因依赖组与对照组比较差异有显著性 在整个研究过程中。 这种脑电图模式可能代表残留的 可卡因依赖患者的神经系统改变，可能是一个因素 导致治疗复发。 可卡因的P300脑成分 依赖型被试在视觉和听觉认知任务上的成绩降低。 在斯滕贝格记忆任务中， 可卡因依赖者在两个月的时间里， 禁欲 因此，可卡因治疗干预的有效性 依赖现在可以通过客观的神经生理学和 业绩计量。