EFFECTS OF ATROPINE ON COGNITIVE INFORMATION PROCESSING

阿托品对认知信息处理的影响

• 批准号: 3853770
• 负责人: R I HERNING
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853770
• 关键词: atropine; cholinergic agents; cognition disorders; drug adverse effect; electroencephalography; evoked potentials; human subject; neural information processing; performance

An extensive battery of sensory and cognitive electrophysiological tasks is used to assess sensory, cognitive and performance deficits produced by atropine. The tasks include eyes open and eyes closed EEG, brainstem auditory evoked response, pattern reversal visual evoked response, the auditory rare event monitoring task, auditory continuous performance task and Sternberg auditory memory task (both immediate and delayed). Each of four doses of atropine (0, 2, 4 and 6 mg/70 kg) is investigated on two occasions. Eight subjects have been tested on these procedures. The purpose of the study is to better understand the effects of cholinergic agents on cognition and performance; in particular, where in the information processing sequence atropine exerts its effects. The EEG and evoked response data have been reported in military and scientific journals. Atrophine at doses 4 mg or greater increase EEG slowing and reduces cognitive evoked potentials and performance. The EEG results were published and evoked potential analysis began over the last year.

一系列广泛的感觉和认知电生理任务 被用来评估感官，认知和性能缺陷所产生的 阿托品。 任务包括睁眼和闭眼EEG、脑干 听觉诱发反应，图形翻转视觉诱发反应， 听觉稀有事件监测任务，听觉连续执行任务 和斯滕贝格听觉记忆任务（包括即时和延迟）。 中的每 研究了四种剂量的阿托品（0、2、4和6 mg/70 kg）对两个 场合 8名受试者接受了这些程序的测试。 这项研究的目的是为了更好地了解 胆碱能药物对认知和表现的影响;特别是， 信息处理序列阿托品发挥其作用。 脑电图 在军事和科学领域， 期刊 阿托品在4 mg或更高剂量下增加EEG减慢和 降低认知诱发电位和表现。 脑电图结果 并在去年开始进行诱发电位分析。