TIME TRENDS IN THE INCIDENCE OF BILIARY ATRESIA

肝外胆道闭锁是一种早期表现的肝病。 婴儿期，表现为肝外胆汁逐渐闭塞 风管。据估计，它的发病率从每8000人中有一人到每15000人中有一人。 活产，并且是表现为 儿童肝移植。所有的发病率数字都不是基于 关于一个明确界定的地缘政治区域；对 这种情况是从转诊中心得出的。一些调查人员已经 提出了这种情况的时空聚集性。 这个项目收集了所有人的出生证明和其他信息 病例发生在俄亥俄州出生超过12年的儿童中。 确诊了94个病例，对应率为0.5 病例/出生10,000例。病例将与其他出生的婴儿进行比较。 关于发病率和聚集性变化的证据的州。一批 将对这种情况的潜在风险因素进行检查。

Extrahepatic biliary atresia is a liver disease presenting in early infancy, manifested by progressive obliteration of the extrahepatic bile ducts. It has been estimated to occur in from one per 8000 to one per 15000 live births, and is the single most common indication for performance of liver transplantation in children. None of the incidence figures is based on a well defined geopolitical region; most estimates of the frequency of this condition are derived from referral centers. Some investigators have suggested a time-space clustering of this condition. This project has gathered birth certificates and other information on all cases occurring among children born over a period of 12 years in Ohio. Ninety-four (94) cases were identified, corresponding to a rate of 0.5 cases/10,000 births. Cases will be compared to the other births in the state for evidence of changes in incidence and clustering. A number of potential risk factors for the condition will be examined.