TIME TRENDS IN THE INCIDENCE OF BILIARY ATRESIA

肝外胆道闭锁是一种早期表现的肝病。 婴儿期，表现为肝外器官逐渐闭塞 胆管。据估计，每8000人中就有一人发生这种情况。 到每15000名活产中就有一名，这是最常见的 儿童肝移植的适应证。 没有一个发病数字是基于明确定义的 地缘政治区域；对这种情况频率的大多数估计 条件是从转诊中心得出的。一些调查人员 提出了这种情况的时空聚集性。 这个项目收集了出生证明和其他信息 所有病例发生在出生在12岁以上的儿童中 在俄亥俄州待了几年。已经确认了94个病例， 相应的比率为0.5例/万名新生儿。案件将会是 与该州其他出生的婴儿进行比较，以寻找变化的证据 在发病率和聚集性上。一些潜在的风险因素 因为情况将会被检查。

Extrahepatic biliary atresia is a liver disease presenting in early infancy, manifested by progressive obliteration of the extrahepatic bile ducts. It has been estimated to occur in from one per 8000 to one per 15000 live births, and is the single most common indication for performance of liver transplantation in children. None of the incidence figures is based on a well defined geopolitical region; most estimates of the frequency of this condition are derived from referral centers. Some investigators have suggested a time-space clustering of this condition. This project has gathered birth certificates and other information on all cases occurring among children born over a period of 12 years in Ohio. Ninety-four (94) cases were identified, corresponding to a rate of 0.5 cases/10,000 births. Cases will be compared to the other births in the state for evidence of changes in incidence and clustering. A number of potential risk factors for the condition will be examined.