TIME TRENDS IN THE INCIDENCE OF BILIARY ATRESIA

肝外胆道闭锁是一种肝脏疾病， 婴儿期，表现为肝外胆汁进行性闭塞 管道 据估计，每8000人中有一人发生， 15000例活产，是最常见的性能指标 儿童肝移植 没有一个发病率数字是 基于一个明确定义的地缘政治区域;大多数估计 这种情况的频率来自转诊中心。 一些 研究人员提出了这种情况的时空聚类。 该项目将收集所有案件的信息，在一个明确的 地缘政治地区约10年，出生证明将 获得。 病例将与该地区的其他出生病例进行比较， 发病率和聚集性变化的证据。 预计A 将于1986年选定地点并开始实地工作。

Extrahepatic biliary atresia is a liver disease presenting in early infancy, manifested by progressive obliteration of the extrahepatic bile ducts. It has been estimated to occur in from one per 8000 to one per 15000 live births, and is the single most common indication for performance of liver transplantation in children. None of the incidence figures is based on a well defined geopolitical region; most estimates of the frequency of this condition are derived from referral centers. Some investigators have suggested a time-space clustering of this condition. This project will gather information on all cases in a well defined geopolitical area for approximately 10 years, and birth certificates will be obtained. Cases will be compared to the other births in the area for evidence of changes in incidence and clustering. It is anticipated that a site will be selected and field work begin in 1986.