CARDIOVASCULAR FLOW DYNAMICS--IN VIVO STUDIES

该项目继续对心内血流动力学进行研究 彩色多普勒超声图像的数字化采集与分析 量化病理生理血流动力学异常的技术。 使用流体力学原理(喷流理论、动量连续性 保护、中心线加速、近端血流收敛和 湍流/粘性相互作用)，时间和空间量化 流动事件是可能的。 在临床处理瓣膜返流时，准确、准确 评估反流的严重程度是非常重要的。 多普勒超声心动图技术增强了非侵入性 瓣膜返流的评估。然而，已经有了， 到目前为止，还没有与这些技术的临床适用性相关的研究 使用严格量化的参考标准进行验证的技术。 出于这个原因，本年度的努力已应用于二尖瓣 和主动脉瓣关闭不全。正在调查的主要地区有 已：1)回流喷口尺寸，2)回流喷口面积和 3)返流近端加速曲线。无创多普勒 通过在体内验证的方法，提供了关于 心脏瓣膜返流严重程度对患者临床的帮助 管理层。

This project has continued studies of intracardiac flow dynamics with digital acquisition and analysis of color Doppler ultrasound imaging techniques for quantifying pathophysiologic hemodynamic abnormalities. Using hydrodynamic principles (jet flux theory, momentum continuity preservation, centerline acceleration, proximal flow convergence and turbulent/viscous interactions), temporal and spatial quantification of flow events is possible. In the clinical management of valvular regurgitation, accurate evaluation of the severity of regurgitation is of major importance. Doppler echocardiographic techniques have enhanced the non invasive assessment of valvular regurgitation. However, there have been, heretofore, no studies related to the clinical applicability of these techniques using strictly quantified reference standards for validation. For this reason the current year's efforts have been applied to mitral and aortic regurgitation. The major areas under investigation have been: 1) regurgitation jet dimensions, 2) regurgitant orifice areas and 3) regurgitant proximal acceleration profiles. Non invasive Doppler methods, thus validated in vivo, provide reliable information about the severity of cardiac valvular regurgitation to aid patient clinical management.