CARDIOVASCULAR FLOW DYNAMICS--IN VIVO STUDIES

本项目强调研究使用新的 新兴的强大的非侵入性超声成像技术， 量化结构和功能性心血管病理。 利用流体动力学原理， 心脏结构异常和病理生理性血流事件 的描述和量化验证。在临床 心功能不全的管理，定量准确 评估对于诊断、预后和 疗法此外，非侵入性评估在经济上 令人向往为此，本年度的努力已扩大到 前几年的研究包括：1）实时，三维 (i.e.四维）超声心动图确定右 右心室存在时的心室每搏输出量 容量超负荷; 2）直接测量三维 重建的血流会聚等速表面积， 定量主动脉瓣反流; 3）收缩静脉成像， 彩色多普勒血流图预测二尖瓣病变程度 反流; 4）彩色多普勒成像缩脉， 定量主动脉瓣返流; 5）使用数字彩色多普勒 用于计算主动脉瓣反流量的血流标测和6） 数字化估测主动脉瓣口有效面积 多普勒彩色血流图。类似的研究正在进行中， 冠状动脉疾病的动物模型。这些研究直接 临床相关性和适用性。

This project emphasizes studies using newly emerging robust non invasive ultrasonic imaging technologies for quantifying structural and functional cardiovascular pathology. Using hydrodynamic principles, temporal and spatial aspects of cardiac structural abnormalities and pathophysiologic flow events are described and their quantification validated. In the clinical management of cardiac dysfunction, quantitatively accurate assessment is of major importance for diagnosis, prognosis and therapy. Non invasive assessment is, in addition, economically desirable. To these ends, the current year's efforts have extended previous years' studies to include: 1) real-time, three-dimensional (i.e. four-dimensional) echocardiography for determining right ventricular stroke volume in the presence of right ventricular volume overload; 2) direct measurement of three-dimensionally reconstructed flow convergence isovelocity surface area for quantifying aortic regurgitant flow; 3) vena contracta imaged by Doppler color flow mapping for predicting the severity of mitral regurgitation; 4) imaging the vena contracta by color Doppler for quantifying aortic regurgitation; 5) the use of digital color Doppler flow mapping for calculating aortic regurgitant volume and 6) estimating aortic regurgitant effective orifice area by digital Doppler color flow mapping. Similar studies are on-going using animal models of coronary artery disease. These studies have direct clinical relevance and applicability.