MUTANT GENE RESOURCE

突变基因资源

• 批准号: 3103386
• 负责人: MURIEL T DAVISSON
• 金额: $ 30.56万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103386
• 关键词: animal breeding; animal colony; animal population genetics; chromosome disorders; embryo /fetus preservation; endocrine disorder; gene mutation; immunogenetics; inbreeding; laboratory mouse; linkage mapping; nervous system disorder; tissue resource /registry

The specific aims of this project are: 1. To procure new potentially valuable neurological, immunological and endocrinological mutants of mice that occur spontaneously in the breeding colonies of the Jackson Laboratory; 2. To characterize the new mutations genetically with respect to mode of inheritance, allelism, and linkage relationship; 3. To characterize the new mutants phenotypically with respect to fertility, longevity, growth, viability, and behavior; 4. To study the anatomical, histopathological, and physiological abnormalities of selected new mutants; 5. To develop suitable strains for maintaining and studying new and established mouse mutations so as to keep the mutant and normal allele segregating on a uniform genetic background; 6. To preserve established mutants as frozen embryos to assure their continued availability; 7. To make mutants and mutant-bearing mice available to the scientific community.

本项目的具体目标是：1。潜在地获取新的