Defining mechanisms of follistatin-mediated muscle adaptation, for treatment of frailty and muscle-related diseases
Defining mechanisms of follistatin-mediated muscle adaptation, for treatment of frailty and muscle-related diseases
批准号:
nhmrc : 526648
负责人:
A/Pr Paul Gregorevic
金额:
$37.17万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
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英文摘要
Physical frailty-weakness is one of the most common symptoms of serious illness and a key cause of death. I propose to study a new model of skeletal muscle growth, to learn more about the causes of wasting in muscle-related diseases. The work will identify cell mechanisms that cause loss of muscle strength, and will help develop novel treatment approaches to prevent or reverse physical frailty in illness. New therapies to combat frailty are vital to improve the health of our community.
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Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions
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批准号:nhmrc : GNT1144772
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项目类别:Project Grants
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资助金额:$83.33万
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财政年份:2018
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负责人:A/Pr Paul Gregorevic
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依托单位:
Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions
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批准号:nhmrc : 1144772
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项目类别:Project Grants
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资助金额:$56.35万
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财政年份:2018
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负责人:A/Pr Paul Gregorevic
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依托单位:
The effects of ACTN3 R577X on muscle wasting and repair, and response to therapy
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批准号:nhmrc : 1130215
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项目类别:Project Grants
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资助金额:$72.83万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Investigating follistatin-based interventions for long term-protection against frailty associated with chronic illness and aging
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批准号:nhmrc : GNT1121500
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项目类别:Project Grants
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资助金额:$98.72万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Investigating follistatin-based interventions for long term-protection against frailty associated with chronic illness and aging
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批准号:nhmrc : 1121500
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项目类别:Project Grants
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资助金额:$67.47万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Using gene delivery technologies to define novel mechanisms of skeletal muscle adaptation, and develop muscle-directed interventions for frailty and serious illness
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批准号:nhmrc : GNT1117835
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项目类别:Research Fellowships
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资助金额:$63.14万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
The effects of ACTN3 R577X on muscle wasting and repair, and response to therapy
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批准号:nhmrc : GNT1130215
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项目类别:Project Grants
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资助金额:$106.61万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Using gene delivery technologies to define novel mechanisms of skeletal muscle adaptation, and develop muscle-directed interventions for frailty and serious illness
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批准号:nhmrc : 1117835
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项目类别:Research Fellowships
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资助金额:$43.17万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Pre-clinical assessment of the therapeutic potential of targeting the Hippo pathway in muscle wasting & muscle-derived cancer
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批准号:nhmrc : GNT1099588
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项目类别:Project Grants
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资助金额:$62.2万
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财政年份:2016
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负责人:A/Pr Paul Gregorevic
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依托单位:
Pre-clinical assessment of the therapeutic potential of targeting the Hippo pathway in muscle wasting & muscle-derived cancer
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批准号:nhmrc : 1099588
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项目类别:Project Grants
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资助金额:$42.65万
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财政年份:2016
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负责人:A/Pr Paul Gregorevic
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依托单位:
Using gene delivery tools to understand and treat skeletal muscle-related disease
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批准号:nhmrc : 1046782
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项目类别:Career Development Fellowships
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资助金额:$30.62万
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财政年份:2013
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负责人:A/Pr Paul Gregorevic
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依托单位:
Novel Muscle Therapeutics Through Selective Beta-Adrenoceptor Signalling
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批准号:nhmrc : 1026231
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项目类别:Project Grants
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资助金额:$40.25万
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财政年份:2012
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负责人:A/Pr Paul Gregorevic
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依托单位:
Investigating Hippo signalling as a novel cause of muscle disease, and as a target for new interventions to combat frailty
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批准号:nhmrc : 1009995
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项目类别:Project Grants
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资助金额:$30.71万
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财政年份:2011
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负责人:A/Pr Paul Gregorevic
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依托单位:
Targeting beta-adrenergic signalling to improve muscle regeneration in muscular dystrophy
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批准号:nhmrc : 509313
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项目类别:NHMRC Project Grants
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资助金额:$31.55万
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财政年份:2008
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负责人:A/Pr Paul Gregorevic
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依托单位:
国内基金
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