Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions

拯救肌营养不良蛋白-糖蛋白复合物以保护肌肉免受消耗状况的影响

• 批准号: nhmrc : 1144772
• 负责人: A/Pr Paul Gregorevic
• 金额: $ 56.35万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rescuing-dystrophin-glycoprotein-wasting-conditions/1320268
• 关键词: Rescuing; dystrophin; glycoprotein; complex; protect

Existing medical strategies to counteract severe muscle wasting disorders are compromised because of dysfunctional signalling around a cluster of proteins called the dystrophin-glycoprotein complex (DGC) located at the muscle membrane. To address this significant unmet medical need, this proposal investigates novel approaches to retain or restore DGC integrity at the muscle membrane with the goals of preserving and protecting muscles during serious wasting conditions.

由于肌膜上一组名为肌营养不良蛋白-糖蛋白复合物（DGC）的蛋白质周围的信号功能失调，现有的对抗严重肌肉萎缩疾病的医学策略受到了损害。为了解决这一重大的未满足的医疗需求，本提案研究了保留或恢复肌肉膜DGC完整性的新方法，目的是在严重消瘦的情况下保存和保护肌肉。