Using gene delivery technologies to define novel mechanisms of skeletal muscle adaptation, and develop muscle-directed interventions for frailty and serious illness

使用基因传递技术来定义骨骼肌适应的新机制，并开发针对虚弱和严重疾病的肌肉定向干预措施

• 批准号: nhmrc : 1117835
• 负责人: A/Pr Paul Gregorevic
• 金额: $ 43.17万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-gene-delivery-frailty-illness/946288
• 关键词: Using; gene; delivery; technologies; define

The focus of my research is to investigate the cellular mechanisms underlying regulation of skeletal muscle size and function in health and disease. By defining these processes we can establish the events contributing to muscle wasting and frailty commonly associated with serious illness and advancing age, and develop interventions to prevent/overcome this important contributor to poor health prospects and reduced survival.

我的研究重点是研究健康和疾病中骨骼肌大小和功能调节的细胞机制。通过定义这些过程，我们可以确定导致肌肉萎缩和虚弱的事件，这些事件通常与严重疾病和年龄增长有关，并制定干预措施来预防/克服这种导致健康前景不佳和生存率降低的重要因素。