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Investigating Hippo signalling as a novel cause of muscle disease, and as a target for new interventions to combat frailty

Investigating Hippo signalling as a novel cause of muscle disease, and as a target for new interventions to combat frailty
研究河马信号作为肌肉疾病的新原因,并作为对抗虚弱的新干预措施的目标
批准号:
nhmrc : 1009995
负责人:
A/Pr Paul Gregorevic
金额:
$30.71万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

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中文摘要
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英文摘要
We will explore the role of the Hippo signaling pathway in muscle development, repair and remodelling. We propose that this little-known pathway which affects organ development, is key for maintaining healthy muscles, and is affected in muscle wasting. Using gene therapy tools to alter this pathway in models of disease, we intend to clarify the role of Hippo signaling in muscle, and establish whether the pathway can be manipulated to treat physical frailty caused by muscle wasting.
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Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions
  • 批准号:
    nhmrc : GNT1144772
  • 项目类别:
    Project Grants
  • 资助金额:
    $83.33万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Gregorevic
  • 依托单位:
Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions
  • 批准号:
    nhmrc : 1144772
  • 项目类别:
    Project Grants
  • 资助金额:
    $56.35万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Gregorevic
  • 依托单位:
The effects of ACTN3 R577X on muscle wasting and repair, and response to therapy
  • 批准号:
    nhmrc : 1130215
  • 项目类别:
    Project Grants
  • 资助金额:
    $72.83万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Paul Gregorevic
  • 依托单位:
Investigating follistatin-based interventions for long term-protection against frailty associated with chronic illness and aging
  • 批准号:
    nhmrc : GNT1121500
  • 项目类别:
    Project Grants
  • 资助金额:
    $98.72万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Paul Gregorevic
  • 依托单位:
国内基金
海外基金
EFNB1激活Hippo/YAP信号通路介导胰腺癌免疫逃逸的机制及靶向干预研究
淫羊藿苷通过TET2介导DNA去甲基化调控Hippo-YAP/TAZ通路逆转绝经后骨质疏松症成血管-成骨耦联失衡的机制研究
Hippo/YAP通路通过HMGB1调控自噬在中耳胆脂瘤角质形成细胞过度增殖中的机制研究
  • 批准号:
    2026JJ50276
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    刘伟
  • 依托单位:
FGFR1OP2 通过 STRIPAK 复合体调控Hippo/YAP 信号通路在多发性骨髓瘤耐药中的作用机制与靶向干预研究
  • 批准号:
    ZCLMS26H0801
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    杨杨
  • 依托单位: