Investigating Hippo signalling as a novel cause of muscle disease, and as a target for new interventions to combat frailty
Investigating Hippo signalling as a novel cause of muscle disease, and as a target for new interventions to combat frailty
批准号:
nhmrc : 1009995
负责人:
A/Pr Paul Gregorevic
金额:
$30.71万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
We will explore the role of the Hippo signaling pathway in muscle development, repair and remodelling. We propose that this little-known pathway which affects organ development, is key for maintaining healthy muscles, and is affected in muscle wasting. Using gene therapy tools to alter this pathway in models of disease, we intend to clarify the role of Hippo signaling in muscle, and establish whether the pathway can be manipulated to treat physical frailty caused by muscle wasting.
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Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions
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批准号:nhmrc : GNT1144772
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项目类别:Project Grants
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资助金额:$83.33万
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财政年份:2018
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负责人:A/Pr Paul Gregorevic
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依托单位:
Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions
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批准号:nhmrc : 1144772
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项目类别:Project Grants
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资助金额:$56.35万
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财政年份:2018
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负责人:A/Pr Paul Gregorevic
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依托单位:
The effects of ACTN3 R577X on muscle wasting and repair, and response to therapy
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批准号:nhmrc : 1130215
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项目类别:Project Grants
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资助金额:$72.83万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Investigating follistatin-based interventions for long term-protection against frailty associated with chronic illness and aging
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批准号:nhmrc : GNT1121500
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项目类别:Project Grants
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资助金额:$98.72万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Investigating follistatin-based interventions for long term-protection against frailty associated with chronic illness and aging
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批准号:nhmrc : 1121500
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项目类别:Project Grants
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资助金额:$67.47万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
The effects of ACTN3 R577X on muscle wasting and repair, and response to therapy
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批准号:nhmrc : GNT1130215
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项目类别:Project Grants
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资助金额:$106.61万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Using gene delivery technologies to define novel mechanisms of skeletal muscle adaptation, and develop muscle-directed interventions for frailty and serious illness
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批准号:nhmrc : GNT1117835
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项目类别:Research Fellowships
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资助金额:$63.14万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Using gene delivery technologies to define novel mechanisms of skeletal muscle adaptation, and develop muscle-directed interventions for frailty and serious illness
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批准号:nhmrc : 1117835
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项目类别:Research Fellowships
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资助金额:$43.17万
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财政年份:2017
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负责人:A/Pr Paul Gregorevic
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依托单位:
Pre-clinical assessment of the therapeutic potential of targeting the Hippo pathway in muscle wasting & muscle-derived cancer
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批准号:nhmrc : GNT1099588
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项目类别:Project Grants
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资助金额:$62.2万
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财政年份:2016
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负责人:A/Pr Paul Gregorevic
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依托单位:
Pre-clinical assessment of the therapeutic potential of targeting the Hippo pathway in muscle wasting & muscle-derived cancer
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批准号:nhmrc : 1099588
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项目类别:Project Grants
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资助金额:$42.65万
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财政年份:2016
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负责人:A/Pr Paul Gregorevic
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依托单位:
Using gene delivery tools to understand and treat skeletal muscle-related disease
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批准号:nhmrc : 1046782
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项目类别:Career Development Fellowships
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资助金额:$30.62万
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财政年份:2013
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负责人:A/Pr Paul Gregorevic
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依托单位:
Novel Muscle Therapeutics Through Selective Beta-Adrenoceptor Signalling
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批准号:nhmrc : 1026231
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项目类别:Project Grants
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资助金额:$40.25万
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财政年份:2012
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负责人:A/Pr Paul Gregorevic
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依托单位:
Defining mechanisms of follistatin-mediated muscle adaptation, for treatment of frailty and muscle-related diseases
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批准号:nhmrc : 526648
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项目类别:NHMRC Project Grants
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资助金额:$37.17万
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财政年份:2009
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负责人:A/Pr Paul Gregorevic
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依托单位:
Targeting beta-adrenergic signalling to improve muscle regeneration in muscular dystrophy
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批准号:nhmrc : 509313
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项目类别:NHMRC Project Grants
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资助金额:$31.55万
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财政年份:2008
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负责人:A/Pr Paul Gregorevic
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依托单位:
国内基金
海外基金
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