PRODUCTION OF HYBRIDOMAS

杂交瘤的生产

• 批准号: 3875201
• 负责人: R SIRAGANIAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3875201
• 关键词: antibody receptor; antibody specificity; antimicroorganism antibody; antireceptor antibody; histamine release; human tissue; hybridomas; immunoglobulin E; laboratory mouse; laboratory rat; mast cell; microorganism immunology; monoclonal antibody; oral bacteria

Hybridomas are being produced which secrete monoclonal antibodies of defined antigen specificity. Hybridomas have been produced against the high affinity IgE (Fc[epsilon]RI) receptor subunits of rat mast cells, to human IgE, and several that modulate histamine release from human or rat mast cells. These monoclonal antibodies are being used for biochemical and biological studies.

产生的杂交瘤分泌的单克隆抗体 确定抗原特异性。杂交瘤的产生是为了对抗 大鼠肥大细胞的IgE（Fc[RI]）受体亚单位对人的亲和力 IgE和几种调节人或大鼠肥大细胞释放组胺的药物 细胞这些单克隆抗体正被用于生物化学和 生物学研究。