MECHANISMS OF HISTAMINE RELEASE

组胺释放机制

• 批准号: 3753419
• 负责人: R SIRAGANIAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3753419
• 关键词: antibody receptor; basophils; biological models; calcium channel; gonadotropin releasing factor; histamine release; immunoglobulin E; immunoregulation; inflammation; ionophores; leukocyte activation /transformation; mast cell; mutant; neoplastic cell culture for noncancer research; secretion; tissue /cell culture

Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflamation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, other secretagogues, LHRH peptides, and the calcium ionophore A23187. Cultured rat b asophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.

正在研究肥大细胞和血液嗜碱性粒细胞释放组胺 作为参与炎症的免疫机制之一。 是 也是细胞分泌的模型。 在组胺释放剂中 所用的是IgE抗体、其它促分泌素、LHRH肽， 钙离子载体A23187。 培养的大鼠B嗜中性白血病细胞是 用作IgE受体和生物化学研究的模型 细胞活化过程中的变化。 可以获得大量的细胞 用于生物化学研究，已经选择了 在细胞活化途径中的不同位点有缺陷， 分泌物