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MECHANISM OF HISTAMINE RELEASE

MECHANISM OF HISTAMINE RELEASE
组胺释放机制
批准号:
3963683
负责人:
R SIRAGANIAN
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
肥大细胞和嗜碱性粒细胞释放组胺的研究 参与炎症的免疫学机制之一。它也是一种 细胞分泌的模型。在使用的组胺释放剂中 包括IgE抗体、过敏毒素、LHRH多肽和钙离子载体 A23187。用培养的大鼠嗜碱性粒细胞白血病细胞作为模型。 细胞免疫球蛋白E受体及其生化变化的研究 激活。可以获得大量的细胞用于生化研究 已经选择了有缺陷的生化变种 在细胞激活和分泌途径中的不同位置。
英文摘要
Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, the anaphylatoxins, LHRH peptides, and the Ca2+ ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.
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PRODUCTION OF HYBRIDOMAS
MECHANISMS OF HISTAMINE RELEASE
PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
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