MECHANISM OF HISTAMINE RELEASE

组胺释放机制

• 批准号: 3963683
• 负责人: R SIRAGANIAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3963683
• 关键词: anaphylatoxins; antihistamines; basophils; complement; histamine release; host organism interaction; immunoglobulin E; immunoregulation; inflammation; ionophores; leukemia; lymphokines; microorganism antigen; mutant; secretion; serum; tissue /cell culture

Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, the anaphylatoxins, LHRH peptides, and the Ca2+ ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.

肥大细胞和血液嗜碱性粒细胞释放的组胺正在被研究为 参与炎症的免疫机制之一。 它也是一个 细胞分泌模型。 使用的组胺释放剂中 是 IgE 抗体、过敏毒素、LHRH 肽和 Ca2+ 离子载体 A23187。 培养的大鼠嗜碱性白血病细胞被用作模型 IgE 受体和细胞过程中生化变化的研究 激活。 可以获得大量细胞用于生化研究 并选择了有缺陷的生化变体 细胞激活和分泌途径中的不同位点。