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MECHANISM OF HISTAMINE RELEASE

MECHANISM OF HISTAMINE RELEASE
组胺释放机制
批准号：
3939895
负责人：
R SIRAGANIAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3939895
关键词：
anaphylatoxins antihistamines basophils complement histamine release host organism interaction immunoglobulin E immunoregulation inflammation ionophores leukemia leukocyte activation /transformation lymphokines mast cell microorganism antigen mutant secretion serum tissue /cell culture

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中文摘要
翻译
肥大细胞和血液嗜碱性粒细胞释放组胺， 作为一种免疫学机制， 炎症 它也是细胞分泌的模型。 中 所用的组胺释放剂是IgE抗体， 过敏毒素、LHRH肽和Ca2+离子载体A23187。 使用培养的大鼠嗜碱性白血病细胞作为模型， IgE受体和细胞周期中生化变化的研究 activation. 可以获得大量的细胞， 已经选择了生物化学研究和生物化学变体， 在细胞增殖途径中的不同位点有缺陷 激活和分泌。
英文摘要
Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, the anaphylatoxins, LHRH peptides, and the Ca2+ ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.
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PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
MECHANISMS OF HISTAMINE RELEASE
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