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MECHANISMS OF HISTAMINE RELEASE

MECHANISMS OF HISTAMINE RELEASE
组胺释放机制
批准号：
3875170
负责人：
R SIRAGANIAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3875170
关键词：
antibody receptor antihistamines basophils calcium transporting ATPase histamine release host organism interaction immunoglobulin E immunoregulation inflammation ionophores laboratory rat leukemia leukocyte activation /transformation mast cell secretion tissue /cell culture

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中文摘要
翻译
肥大细胞和血液嗜碱性细胞的组胺释放被研究为
英文摘要
Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody and other secretagogues including LHRH peptides and the Ca 2+ ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of these cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.
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PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
MECHANISMS OF HISTAMINE RELEASE
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