MUTANT GENE RESOURCE

突变基因资源

• 批准号: 3103385
• 负责人: MURIEL T DAVISSON
• 金额: $ 29.4万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103385
• 关键词: animal breeding; animal colony; animal population genetics; chromosome disorders; embryo /fetus preservation; endocrine disorder; gene mutation; immunogenetics; inbreeding; laboratory mouse; linkage mapping; nervous system disorder; tissue resource /registry

The specific aims of this project are: 1. To procure new potentially valuable neurological, immunological and endocrinological mutants of mice that occur spontaneously in the breeding colonies of the Jackson Laboratory; 2. To characterize the new mutations genetically with respect to mode of inheritance, allelism, and linkage relationship; 3. To characterize the new mutants phenotypically with respect to fertility, longevity, growth, viability, and behavior; 4. To study the anatomical, histopathological, and physiological abnormalities of selected new mutants; 5. To develop suitable strains for maintaining and studying new and established mouse mutations so as to keep the mutant and normal allele segregating on a uniform genetic background; 6. To preserve established mutants as frozen embryos to assure their continued availability; 7. To make mutants and mutant-bearing mice available to the scientific community.

该项目的具体目标是：1。为了获得新的潜在的 小鼠的有价值的神经学、免疫学和内分泌学突变体 在杰克逊的繁殖地自然发生 实验室; 2。从基因上描述新的突变 遗传方式、等位性和连锁关系; 3.到 表征新突变体在生育力方面的表型， 寿命、生长、生存能力和行为; 4.为了研究解剖学， 所选新突变体的组织病理学和生理学异常; 5.培育合适的菌种，以保持和研究新的和 建立小鼠突变，以保持突变和正常等位基因， 在统一的遗传背景上分离; 6.维护既定 突变体作为冷冻胚胎，以确保其持续可用性; 7.到 使突变体和携带突变体的小鼠可供科学界使用。