REACTION OF FREE RADICAL METABOLITES WITH DNA
REACTION OF FREE RADICAL METABOLITES WITH DNA
批准号:
3876931
负责人:
R P MASON
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
自由基代谢物与DNA的相互作用一直是一个主要的研究领域
英文摘要
The interaction of free radical metabolites with DNA has been a major area
of interest and speculation, but previous electron spin resonance (ESR)
investigations of this area have been very limited. The reaction of the
hydroxyl radical, generated by a Fenton system, with pyrimidine
deoxyribonucleotides was investigated using the ESR technique of spin
trapping. The spin trap t-nitrosobutane was employed to trap secondary
radicals formed by the reaction of the hydroxyl radical with these
nucleotides. The results presented here show the hydroxyl radical attack on
thymidine, 2-deoxycytidine 5-monophosphate and 2-deoxyuridine
5-monophosphate produced nucleotide-derived free radicals. The results
indicate that OH radical attack occurs predominantly at the carbon-carbon
double bond of the pyrimidine base. The ESR studies showed a good
correlation with previous work produced by authors who used x- or gamma-ray
irradiation to generate the hydroxyl radical. A thiobarbituric acid assay
was also used to monitor the damage produced to the nucleotides by the
Fenton system. These results showed qualitative agreement with the spin
trapping studies.
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会议论文
RADICAL ANION METABOLITES
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批准号:4693236
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
PHENYL RADICAL FORMATION BY OXYHEMOGLOBIN FROM PHENYLHYDRAZINE IN VIVO
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批准号:3918695
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
RELATIONSHIP OF FREE RADICALS TO HALOCARBON-INDUCED TOXICITY IN THE LIVER
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批准号:3918692
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
PORPHYRIN ION RADICAL METABOLITES AND THEIR REACTIONS
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批准号:3876932
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
REACTION OF FREE RADICAL METABOLITES WITH DNA
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批准号:3918693
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
PORPHYRIN ION RADICAL METABOLITES AND THEIR REACTIONS
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批准号:3918694
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
THE MECHANISM OF REDUCTION OF TOXIC CHEMICALS AND DRUGS
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批准号:3841111
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
THE MECHANISM OF REDUCTION OF TOXIC CHEMICALS AND DRUGS
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批准号:3855932
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
RELATIONSHIP OF FREE RADICALS TO HALOCARBON-INDUCED TOXICITY IN THE LIVER
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批准号:3876930
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
OXIDATION OF AGRANULOCYTOSIS CAUSING DRUGS BY MYELOPEROXIDASE
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批准号:3755463
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
TRANSITION-METAL MEDIATED FREE RADICAL FORMATION IN VITRO AND IN VIVO
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批准号:3777537
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
IN VIVO DETECTION OF FREE RADICALS AND NITRIC OXIDE IN TOXICITY
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批准号:3777543
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
PORPHYRIN ION RADICAL METABOLITES AND THEIR REACTIONS
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批准号:3855919
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
IN VIVO DETECTION OF FREE RADICALS AND NITRIC OXIDE IN TOXICITY
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批准号:3755460
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:R P MASON
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依托单位:
OXIDATION OF AGRANULOCYTOSIS CAUSING DRUGS BY MYELOPEROXIDASE
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批准号:3777546
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
TRANSITION-METAL MEDIATED FREE RADICAL FORMATION IN VITRO AND IN VIVO
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批准号:3841110
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
HYDROPEROXIDE DERIVED FREE RADICALS
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批准号:6162247
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
NITRIC OXIDE AND THE METABOLISM OF TOXIC CHEMICALS AND DRUGS
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批准号:6162248
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
FREE RADICAL METABOLITE FORMATION BY PEROXIDASES
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批准号:4693237
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
PHENYL RADICAL FORMATION BY OXYHEMOGLOBIN FROM PHENYLHYDRAZINE IN VIVO
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批准号:3876933
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R P MASON
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依托单位:
海外基金