Enhancing the population-wide Northern Ireland Registry of Self-Harm and Suicide Ideation through data linkage

通过数据链接加强北爱尔兰全民自残和自杀意念登记

• 批准号: ES/R011400/1
• 负责人: Dermot O'Reilly
• 金额: $ 20.06万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FR011400%2F1
• 关键词: Enhancing; population; wide; Northern; Ireland

Self-Harm and suicide ideation (i.e. thoughts about dying by suicide) are two of the most important known risk factors for death by suicide. Increasing suicide rates are a major public health concern and Northern Ireland consistently has the highest rate of suicide in the UK and Ireland. Recent policies to reduce the rates of suicide nationwide are now including a focus on reducing self-harm and suicide ideation as these are precursors to suicide. However, little is known about what causes self-harm and suicide ideation, how these two factors are related and what impact they have on mortality risk either individually or in combination. Understanding the individual level, household-level, area-level and health related predictors for self-harm and suicide is of vital public health importance so that intervention services can be targeted accurately. Northern Ireland is unique in that it has a national Registry of Self-Harm that has collated information on all presentations to emergency department for self-harm and suicide ideation since 2012 (approximately 8,000 per/year) and the research team has secured access to these data from the data custodians in each of the Health and Social Care Trusts. The proposed project will link these data to additional health, social services, Census and death data to generate a unique dataset of health and social information to achieve a better understanding of the risk factors associated with self-harm, suicide ideation and death by suicide. Our researchers partners in the Public Health Agency and each of the five Health Trusts have acknowledged that the increased knowledge from this project could be instrumental in shaping future policies around the prevention and treatment of self-harm and suicide ideation. The overarching aim of the project is to be the first ever population-wide cohort study of both self-harm and suicide ideation, investigating a range of demographic, physical health, mental health and psychosocial factors to tease apart the strength of association between each of these factors and the outcomes of interest to better understand those most at risk. The project will address three overlapping research questions: (i) Which factors are most associated with self-harm/suicide ideation/both, (ii) What happens after self-harm/suicide ideation, and (iii) an evaluation of the 'card before you leave' scheme.The extensive detail in the Registry of Self-Harm, enhanced by linkage to the Enhanced Prescribing Database (population-wide data on all prescriptions dispensed in community pharmacies in NI), the Social Services Client Administration and Retrieval Environment data (population-wide data on interaction with social services), mortality data from the death register and the 2011 Census data, will be used to explore a range of predictors and outcomes of both self-harm and suicide ideation. Prescription medication data will allow for an investigation into whether or not individuals are using their own medication to self-harm by self-poisoning. Census data will allow for the identification of individuals within households to investigate whether individuals are using medication from other household members. We will capitalise on a naturally occurring experiment within the data to evaluate the 'card before you leave' scheme (a treatment pathway for self-harmers deemed low risk) which was rolled out in 2010 by examining outcomes pre- and post-intervention and identifying those individuals eligible who do and do not avail of the scheme.This project will be the first to link the Registry of Self-harm to other data sources and will become a pioneer study to facilitate access to this data for other researchers across the UK. The project will also provide a significant training opportunity for ADRC-NI support staff and the associated researchers, including the named early career researcher.

自残和自杀意念（即关于自杀死亡的想法）是已知自杀死亡的两个最重要的危险因素。自杀率上升是一个主要的公共卫生问题，北爱尔兰的自杀率一直是英国和爱尔兰最高的。最近在全国范围内降低自杀率的政策现在包括关注减少自残和自杀意念，因为这些是自杀的前兆。然而，关于什么导致自残和自杀意念，这两个因素是如何关联的，以及它们对死亡风险的影响是单独的还是联合的，我们知之甚少。了解个人层面、家庭层面、地区层面和与健康相关的自残和自杀预测因素对公共卫生至关重要，从而能够准确地提供有针对性的干预服务。北爱尔兰的独特之处在于，它拥有一个国家自残登记处，该登记处整理了自2012年以来所有向急诊科提交的自残和自杀念头的信息（每年约8000人），研究小组已从每个卫生和社会保健信托基金的数据保管人那里获得了这些数据。拟议的项目将把这些数据与其他健康、社会服务、人口普查和死亡数据联系起来，形成一个独特的健康和社会信息数据集，以便更好地了解与自残、自杀意念和自杀死亡有关的风险因素。我们在公共卫生机构的研究伙伴和五个卫生信托基金中的每一个都承认，从这个项目中增加的知识可能有助于制定未来有关预防和治疗自残和自杀念头的政策。该项目的首要目标是成为有史以来第一个针对自残和自杀意念的人口范围队列研究，调查一系列人口统计学、身体健康、心理健康和社会心理因素，梳理出这些因素与相关结果之间的联系强度，以更好地了解那些风险最大的因素。该项目将解决三个重叠的研究问题：(i)哪些因素与自残/自杀意念/两者最相关，（ii）自残/自杀意念后会发生什么，以及（iii）对“离开前卡片”计划的评估。自残登记处的大量详细资料将被用于探索自残和自杀意念的一系列预测因素和结果，这些资料将通过与增强型处方数据库（全国范围内社区药房分发的所有处方的数据）、社会服务客户管理和检索环境数据（全国范围内与社会服务互动的数据）、死亡登记册中的死亡率数据和2011年人口普查数据的联系得到加强。处方药物数据将允许调查个人是否使用自己的药物通过自我中毒来自残。人口普查数据将允许识别家庭中的个人，以调查个人是否正在使用其他家庭成员提供的药物。我们将利用数据中的一个自然发生的实验来评估2010年推出的“离开前卡”计划（一种被认为是低风险的自残者的治疗途径），通过检查干预前后的结果，并确定那些符合条件的人，他们利用和不利用该计划。该项目将是第一个将自残登记处与其他数据源联系起来的项目，并将成为一项先驱研究，以促进英国其他研究人员访问这些数据。该项目还将为ADRC-NI支持人员和相关研究人员提供重要的培训机会，包括指定的早期职业研究人员。

项目成果

OP30 What happens after self-harm? An exploration of self-harm and suicide using the northern ireland registry of self-harm

OP30 自残后会发生什么？

• 发表时间: 2019
• 期刊: Journal of Epidemiology & Community Health
• 影响因子: 6.3
• 作者: Maguire A

Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales.

• DOI: 10.1016/s0140-6736(22)01656-7
• 发表时间: 2022-10-15
• 期刊: Lancet (London, England)

What happens after self-harm? An exploration of self-harm and suicide using the Northern Ireland Registry of Self-Harm

自残后会发生什么？

• DOI: 10.23889/ijpds.v4i3.1186
• 发表时间: 2019
• 期刊: International Journal of Population Data Science
• 作者: Maguire A

Impact of the COVID-19 pandemic on Self-Harm and self-harm/suicide Ideation and subsequent mortality in Northern Ireland: a longitudinal, population-wide data linkage study.

• DOI: 10.23889/ijpds.v7i3.1899
• 发表时间: 2022-08-25
• 期刊: International Journal of Population Data Science

Protocol for the development of the Wales Multimorbidity e-Cohort (WMC): data sources and methods to construct a population-based research platform to investigate multimorbidity.

• DOI: 10.1136/bmjopen-2020-047101
• 发表时间: 2021-01-19
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Lyons J;Akbari A;Agrawal U;Harper G;Azcoaga-Lorenzo A;Bailey R;Rafferty J;Watkins A;Fry R;McCowan C;Dezateux C;Robson JP;Peek N;Holmes C;Denaxas S;Owen R;Abrams KR;John A;O'Reilly D;Richardson S;Hall M;Gale CP;Davies J;Davies C;Cross L;Gallacher J;Chess J;Brookes AJ;Lyons RA
• 通讯作者: Lyons RA