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Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer

Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer
定义鞘氨醇激酶 1 棕榈酰化变体在癌症中的作用
批准号:
nhmrc : 1084772
负责人:
Prof Stuart Pitson
金额:
$40.24万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31

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中文摘要
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英文摘要
Sphingosine kinase is a protein that when dysregulated is involved in cancer development and progression. We have recently made a substantial breakthrough in this area by identifing a naturally occuring variant of sphingosine kinase that is constantly activated and has an enhanced ability to induce cancer. In this study we will examine and target this form of sphingosine kinase as a potential therapeutic intervention in cancer.
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Targeting sphingolipid metabolism in disease
  • 批准号:
    nhmrc : GNT1156693
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.92万
  • 财政年份:
    2019
  • 负责人:
    Prof Stuart Pitson
  • 依托单位:
Sphingosine kinase as a target for anti-cancer therapy
  • 批准号:
    nhmrc : GNT1042589
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $59.08万
  • 财政年份:
    2013
  • 负责人:
    Prof Stuart Pitson
  • 依托单位:
Sphingosine kinase as a target for anti-cancer therapy
  • 批准号:
    nhmrc : 1042589
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $50.1万
  • 财政年份:
    2013
  • 负责人:
    Prof Stuart Pitson
  • 依托单位:
Targetting the CIB1-sphingosine kinase interaction in oncogenesis
  • 批准号:
    nhmrc : 1004695
  • 项目类别:
    Project Grants
  • 资助金额:
    $53.68万
  • 财政年份:
    2011
  • 负责人:
    Prof Stuart Pitson
  • 依托单位:
国内基金
海外基金
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
Sestrin2抑制内质网应激对早产儿视网膜病变的调控作用及其机制研究
  • 批准号:
    82371070
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    赵培泉
  • 依托单位: