Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer

定义鞘氨醇激酶 1 棕榈酰化变体在癌症中的作用

• 批准号: nhmrc : 1084772
• 负责人: Prof Stuart Pitson
• 金额: $ 40.24万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-palmitoylated-1-cancer/519029
• 关键词: Defining; role; palmitoylated; variant; sphingosine

Sphingosine kinase is a protein that when dysregulated is involved in cancer development and progression. We have recently made a substantial breakthrough in this area by identifing a naturally occuring variant of sphingosine kinase that is constantly activated and has an enhanced ability to induce cancer. In this study we will examine and target this form of sphingosine kinase as a potential therapeutic intervention in cancer.

鞘氨酸激酶是一种蛋白质，当调节失调时，它与癌症的发生和发展有关。我们最近在这一领域取得了重大突破，发现了一种自然发生的鞘氨醇激酶变体，这种变体不断被激活，并具有增强的致癌能力。在这项研究中，我们将研究和瞄准这种形式的鞘氨醇激酶作为一种潜在的癌症治疗干预措施。