Targeting sphingolipid metabolism in disease

我的研究一直处于国际前沿，了解鞘脂(一种存在于所有细胞中的分子)的失调如何导致癌症和其他疾病，以及如何针对这一点进行治疗。我的提案详细介绍了研究，以了解鞘磷脂代谢在疾病中是如何改变的，应用方法开发小分子抑制剂作为潜在的抗癌治疗药物，并在高级临床前模型中评估这些发现。

My research has been at the international forefront in understanding how dysregulation of sphingolipids (a type of molecules present in all cells) contributes to cancer and other diseases, and how this can be targeted for therapeutic benefit. My proposal details studies to understand how sphingolipid metabolism is altered in disease, applied approaches to develop small molecule inhibitors as potential anti-cancer therapeutics, and assessment of these findings in advanced pre-clinical models.