Targeting sphingolipid metabolism in disease
Targeting sphingolipid metabolism in disease
批准号:
nhmrc : GNT1156693
负责人:
Prof Stuart Pitson
金额:
$64.92万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 --
中文摘要
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英文摘要
My research has been at the international forefront in understanding how dysregulation of sphingolipids (a type of molecules present in all cells) contributes to cancer and other diseases, and how this can be targeted for therapeutic benefit. My proposal details studies to understand how sphingolipid metabolism is altered in disease, applied approaches to develop small molecule inhibitors as potential anti-cancer therapeutics, and assessment of these findings in advanced pre-clinical models.
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会议论文
Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer
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批准号:nhmrc : 1084772
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项目类别:Project Grants
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资助金额:$40.24万
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财政年份:2015
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负责人:Prof Stuart Pitson
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依托单位:
Sphingosine kinase as a target for anti-cancer therapy
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批准号:nhmrc : GNT1042589
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项目类别:Research Fellowships
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资助金额:$59.08万
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财政年份:2013
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负责人:Prof Stuart Pitson
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依托单位:
Sphingosine kinase as a target for anti-cancer therapy
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批准号:nhmrc : 1042589
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项目类别:Research Fellowships
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资助金额:$50.1万
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财政年份:2013
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负责人:Prof Stuart Pitson
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依托单位:
Targetting the CIB1-sphingosine kinase interaction in oncogenesis
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批准号:nhmrc : 1004695
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项目类别:Project Grants
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资助金额:$53.68万
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财政年份:2011
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负责人:Prof Stuart Pitson
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依托单位:
Role of sphingosine kinase 1 in PP2A-associated tumorigenesis
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批准号:nhmrc : 626937
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项目类别:NHMRC Project Grants
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资助金额:$34.87万
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财政年份:2010
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负责人:Prof Stuart Pitson
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依托单位:
Mechanisms of regulation and biological roles of sphingosine kinase 2
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批准号:nhmrc : 626936
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项目类别:NHMRC Project Grants
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资助金额:$34.54万
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财政年份:2010
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负责人:Prof Stuart Pitson
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依托单位:
The role of SKAM and sphingosine kinase in wound healing
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批准号:nhmrc : 508097
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项目类别:NHMRC Project Grants
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资助金额:$18.76万
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财政年份:2008
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负责人:Prof Stuart Pitson
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 508098
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项目类别:NHMRC Research Fellowships
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资助金额:$38.02万
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财政年份:2008
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负责人:Prof Stuart Pitson
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依托单位:
The molecular mechanisms regulating oncogenic signalling by sphingosine kinase 1 phosphorylation and localisation
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批准号:nhmrc : 453512
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项目类别:NHMRC Project Grants
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资助金额:$31.02万
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财政年份:2007
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负责人:Prof Stuart Pitson
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依托单位:
The molecular mechanism of sphingosine kinase activation
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批准号:nhmrc : 232905
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项目类别:NHMRC Project Grants
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资助金额:$29.51万
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财政年份:2003
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负责人:Prof Stuart Pitson
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依托单位:
Sphingosine kinase activation and its downstream consequences
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批准号:nhmrc : 232910
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项目类别:Career Development Fellowships
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资助金额:$29.04万
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财政年份:2003
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负责人:Prof Stuart Pitson
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依托单位:
海外基金