Role of sphingosine kinase 1 in PP2A-associated tumorigenesis

鞘氨醇激酶 1 在 PP2A 相关肿瘤发生中的作用

• 批准号: nhmrc : 626937
• 负责人: Prof Stuart Pitson
• 金额: $ 34.87万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-sphingosine-kinase-associated-tumorigenesis/98074
• 关键词: Role; sphingosine; kinase; PP2A; associated

Defects in protein phosphatase 2A (PP2A) are widely associated with the development of solid tumors and leukemia. The precise mechanisms whereby defects in PP2A lead to cancer, however, remain undefined. We have recently identified that the oncogenic protein sphingosine kinase 1 (SK1) as a target of PP2A. In this study we will examine the role of SK1 in PP2A-associated cancers. Successful outcomes in these studies will establish SK1 as a target for therapeutic intervention in these cancers.

蛋白磷酸酶2A（PP2A）缺陷与实体瘤和白血病的发展广泛相关。然而，PP2A缺陷导致癌症的确切机制仍不清楚。我们最近发现，致癌蛋白鞘氨醇激酶1（SK 1）作为PP2A的靶点。在这项研究中，我们将研究SK 1在PP2A相关癌症中的作用。这些研究的成功结果将使SK1成为这些癌症治疗干预的靶点。