Targetting the CIB1-sphingosine kinase interaction in oncogenesis

靶向肿瘤发生中的 CIB1-鞘氨醇激酶相互作用

• 批准号: nhmrc : 1004695
• 负责人: Prof Stuart Pitson
• 金额: $ 53.68万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targetting-cib1-sphingosine-interaction-oncogenesis/109063
• 关键词: Targetting; CIB1; sphingosine; kinase; interaction

Sphingosine kinase is a protein involved in cancer development and progression. We have identified that the cancer-inducing activity of sphingosine kinase is controlled by another protein called CIB1 which itself appears involved in causing cancer by deregulating sphingosine kinase. In this study we will examine and target the interaction between sphingosine kinase and CIB1 as a potential therapeutic intervention in cancer.

鞘氨醇激酶是一种参与癌症发生和发展的蛋白。我们已经确定鞘氨醇激酶的致癌活性是由另一种叫做CIB1的蛋白质控制的，而CIB1本身似乎通过解除鞘氨醇激酶的调节而参与致癌。在这项研究中，我们将研究鞘氨醇激酶和CIB1之间的相互作用，并将其作为一种潜在的癌症治疗干预手段。