Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice

放射状胶质细胞成熟延迟与 NFI 缺乏有关，NFI 缺乏是人类和小鼠皮质缺陷的根本原因

• 批准号: nhmrc : 1100443
• 负责人: A/Pr Thomas Burne
• 金额: $ 54.93万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/delayed-radial-glial-humans-mice/662512
• 关键词: Delayed; radial; glial; maturation; linked

The timely generation of neurons and glia is important for brain development and consequently brain function throughout life. Nuclear factor I (NFI) genes are important for regulating the production of neurons and glia, and people with disrupted NFI genes have severe cognitive and motor deficits. Using human genetic data and mouse models, we will analyse how disrupting these genes affects brain development, and changes the overall structure and wiring of the cerebral cortex as well as behaviour.

神经元和神经胶质的及时产生对于大脑发育以及因此大脑在整个生命中的功能是重要的。核因子I（NFI）基因对调节神经元和神经胶质的产生很重要，NFI基因被破坏的人有严重的认知和运动缺陷。利用人类遗传数据和小鼠模型，我们将分析破坏这些基因如何影响大脑发育，并改变大脑皮层的整体结构和布线以及行为。