Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
批准号:
nhmrc : 1100443
负责人:
A/Pr Thomas Burne
金额:
$54.93万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31
中文摘要
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英文摘要
The timely generation of neurons and glia is important for brain development and consequently brain function throughout life. Nuclear factor I (NFI) genes are important for regulating the production of neurons and glia, and people with disrupted NFI genes have severe cognitive and motor deficits. Using human genetic data and mouse models, we will analyse how disrupting these genes affects brain development, and changes the overall structure and wiring of the cerebral cortex as well as behaviour.
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Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
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批准号:nhmrc : GNT1100443
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项目类别:Project Grants
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资助金额:$80.2万
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财政年份:2016
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负责人:A/Pr Thomas Burne
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依托单位:
Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
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批准号:nhmrc : 1099709
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项目类别:Project Grants
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资助金额:$51.81万
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财政年份:2016
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负责人:A/Pr Thomas Burne
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依托单位:
Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
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批准号:nhmrc : GNT1099709
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项目类别:Project Grants
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资助金额:$75.43万
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财政年份:2016
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负责人:A/Pr Thomas Burne
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依托单位:
Does adult vitamin D deficiency increase vulnerability to social stress resulting in altered brain function?
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批准号:nhmrc : GNT1078159
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项目类别:Project Grants
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资助金额:$31.98万
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财政年份:2015
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负责人:A/Pr Thomas Burne
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依托单位:
Does adult vitamin D deficiency increase vulnerability to social stress resulting in altered brain function?
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批准号:nhmrc : 1078159
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项目类别:Project Grants
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资助金额:$21.99万
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财政年份:2015
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负责人:A/Pr Thomas Burne
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依托单位:
Adult vitamin D deficiency and cognitive dysfunction in a mouse model
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批准号:nhmrc : 1070081
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项目类别:Project Grants
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资助金额:$27.95万
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财政年份:2014
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负责人:A/Pr Thomas Burne
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依托单位:
The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
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批准号:nhmrc : 1057882
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项目类别:Project Grants
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资助金额:$24.39万
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财政年份:2014
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负责人:A/Pr Thomas Burne
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依托单位:
Early pharmacological intervention in an animal model of schizophrenia
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批准号:nhmrc : 1042259
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项目类别:Project Grants
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资助金额:$29.26万
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财政年份:2013
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负责人:A/Pr Thomas Burne
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依托单位:
Developmental vitamin D deficiency and prefrontal cortical dysfunction
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批准号:nhmrc : 1024239
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项目类别:Project Grants
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资助金额:$23.71万
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财政年份:2012
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负责人:A/Pr Thomas Burne
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依托单位:
Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
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批准号:nhmrc : 1007677
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项目类别:NHMRC Project Grants
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资助金额:$23.1万
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财政年份:2011
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负责人:A/Pr Thomas Burne
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依托单位:
Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
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批准号:nhmrc : 1002118
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项目类别:Project Grants
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资助金额:$16.86万
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财政年份:2011
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负责人:A/Pr Thomas Burne
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依托单位:
Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
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批准号:nhmrc : 569528
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项目类别:NHMRC Project Grants
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资助金额:$33.44万
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财政年份:2009
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负责人:A/Pr Thomas Burne
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依托单位:
Social behaviour in rats developmentally deficient in Vitamin D: Modelling the negative symptoms of schizophrenia
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批准号:nhmrc : 511066
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项目类别:NHMRC Project Grants
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资助金额:$24.07万
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财政年份:2008
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负责人:A/Pr Thomas Burne
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依托单位:
The Developmental vitamin D model (DVD) as an animal model for schizophrenia
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批准号:nhmrc : 455884
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项目类别:NHMRC Project Grants
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资助金额:$17.21万
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财政年份:2007
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负责人:A/Pr Thomas Burne
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依托单位:
海外基金