Developmental vitamin D deficiency and prefrontal cortical dysfunction
Developmental vitamin D deficiency and prefrontal cortical dysfunction
批准号:
nhmrc : 1024239
负责人:
A/Pr Thomas Burne
金额:
$23.71万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
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英文摘要
The cause of schizophrenia is unknown but is believed to be due to abnormal brain development. Dopamine abnormalities are central to schizophrenia. We have developed a model of maternal vitamin D deficiency in rats, based on disease epidemiology that shows individuals that have low levels of vitamin D at birth have an increased risk of developing schizophrenia later in life. We now also show dopamine systems in regions associated with cognition may develop abnormally in our animal model.
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Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
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Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
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财政年份:2016
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依托单位:
Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
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批准号:nhmrc : 1100443
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项目类别:Project Grants
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资助金额:$54.93万
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财政年份:2016
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依托单位:
Does adult vitamin D deficiency increase vulnerability to social stress resulting in altered brain function?
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批准号:nhmrc : GNT1078159
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资助金额:$31.98万
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负责人:A/Pr Thomas Burne
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依托单位:
Does adult vitamin D deficiency increase vulnerability to social stress resulting in altered brain function?
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资助金额:$21.99万
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依托单位:
The Developmental vitamin D-deficiency animal model of schizophrenia:- Critical window for intervention and optimal dose
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财政年份:2014
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Adult vitamin D deficiency and cognitive dysfunction in a mouse model
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项目类别:Project Grants
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资助金额:$27.95万
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财政年份:2014
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Early pharmacological intervention in an animal model of schizophrenia
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资助金额:$29.26万
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财政年份:2013
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负责人:A/Pr Thomas Burne
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依托单位:
Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
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批准号:nhmrc : 1007677
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项目类别:NHMRC Project Grants
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资助金额:$23.1万
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财政年份:2011
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负责人:A/Pr Thomas Burne
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依托单位:
Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
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批准号:nhmrc : 1002118
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项目类别:Project Grants
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资助金额:$16.86万
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财政年份:2011
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依托单位:
Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
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负责人:A/Pr Thomas Burne
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依托单位:
Social behaviour in rats developmentally deficient in Vitamin D: Modelling the negative symptoms of schizophrenia
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批准号:nhmrc : 511066
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项目类别:NHMRC Project Grants
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资助金额:$24.07万
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财政年份:2008
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负责人:A/Pr Thomas Burne
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依托单位:
The Developmental vitamin D model (DVD) as an animal model for schizophrenia
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批准号:nhmrc : 455884
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项目类别:NHMRC Project Grants
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资助金额:$17.21万
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财政年份:2007
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负责人:A/Pr Thomas Burne
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依托单位:
国内基金
海外基金
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