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Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers

Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
高龄父亲：高龄父亲后代的行为、神经解剖学和基因组相关性
批准号：
nhmrc : 569528
负责人：
A/Pr Thomas Burne
金额：
$33.44万
依托单位：
The University of Queensland
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2009
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2009-01-01 至 2012-12-31
来源：
https://researchdata.edu.au/advanced-paternal-age-older-fathers/94957
关键词：
Advancedpaternalagebehaviouralneuroanatomical

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英文摘要
The offspring of older fathers have an increased risk of developing disorders such as autism and schizophrenia. This is thought to be due to mutations in the developing sperm. Our group has shown in a mouse model that the offspring of older fathers have changes in brain shape and in behaviour, similar to some findings in autism. In this grant we will refine this animal model and explore the brain, behavioural and genetic correlates of advanced paternal age.
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Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
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Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
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  • 依托单位：
    The University of Queensland
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