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Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice

Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
放射状胶质细胞成熟延迟与 NFI 缺乏有关，NFI 缺乏是人类和小鼠皮质缺陷的根本原因
批准号：
nhmrc : GNT1100443
负责人：
A/Pr Thomas Burne
金额：
$80.2万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2016
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2016-01-01 至 --
来源：
https://researchdata.edu.au/delayed-radial-glial-humans-mice/1346121
关键词：
Delayedradialglialmaturationlinked

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英文摘要
The timely generation of neurons and glia is important for brain development and consequently brain function throughout life. Nuclear factor I (NFI) genes are important for regulating the production of neurons and glia, and people with disrupted NFI genes have severe cognitive and motor deficits. Using human genetic data and mouse models, we will analyse how disrupting these genes affects brain development, and changes the overall structure and wiring of the cerebral cortex as well as behaviour.
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