Adult vitamin D deficiency and cognitive dysfunction in a mouse model

成人维生素 D 缺乏和小鼠模型认知功能障碍

• 批准号: nhmrc : 1070081
• 负责人: A/Pr Thomas Burne
• 金额: $ 27.95万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/adult-vitamin-d-mouse-model/455423
• 关键词: Adult; vitamin; deficiency; cognitive; dysfunction

Vitamin D deficiency is common in the Australian adult population. We provide convincing evidence that vitamin D deficiency during adulthood impacts on brain function in a mouse model. If these changes generalize to humans, then this broader program of research could have important public health implications. Vitamin D supplementation is safe and cheap is clearly an attractive candidate for public health intervention.

维生素D缺乏症在澳大利亚成年人中很常见。我们提供了令人信服的证据，证明成年期维生素D缺乏会影响小鼠模型的脑功能。如果这些变化推广到人类，那么这个更广泛的研究计划可能会对公共卫生产生重要影响。维生素D补充剂是安全和廉价的，显然是公共卫生干预的一个有吸引力的候选者。