Does adult vitamin D deficiency increase vulnerability to social stress resulting in altered brain function?

成人维生素 D 缺乏是否会增加对社会压力的脆弱性，从而导致大脑功能改变？

• 批准号: nhmrc : GNT1078159
• 负责人: A/Pr Thomas Burne
• 金额: $ 31.98万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-adult-vitamin-brain-function/1345194
• 关键词: Does; adult; vitamin; deficiency; increase

We propose that first generation migrants exposed to both psychosocial stress and hypovitaminosis D may be less able to buffer stress-related adverse brain outcomes. Our hypothesis is that combined effects of both adult hypovitaminosis D, with the lack of its neuroprotective properties, and the neurochemical effects of social stress will result in an increase in schizophrenia-related behaviours. There is an urgent need for novel animal models based on the epidemiology of schizophrenia.

我们认为，暴露于心理社会压力和维生素D缺乏症的第一代移民可能无法缓冲与压力相关的不良大脑结果。我们的假设是，成人维生素D缺乏症的综合影响，缺乏其神经保护特性，以及社会压力的神经化学作用将导致精神分裂症相关行为的增加。迫切需要基于精神分裂症流行病学的新型动物模型。