IN-UTERO FETAL GROWTH PATTERNS IN RELATION TO OUTCOME AT BIRTH

与出生结果相关的宫内胎儿生长模式

• 批准号: 3898488
• 负责人: H J HOFFMAN
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3898488
• 关键词: alcoholic beverage consumption; body physical characteristic; body weight; child physical development; disease /disorder proneness /risk; embryo /fetus monitoring; gestational age; growth /development; hemoglobin; human birth weight; human pregnant subject; human subject; longitudinal human study; prenatal growth disorder; prenatal stress; statistics /biometry; tobacco abuse; ultrasonography

The project has been expanded to encompass two related research studies. The first study has analyzed data derived from a randomized clinical trial of diagnostic ultrasound use during pregnancy conducted by the team of Norwegian investigators in Trondheim, Norway. The purpose of the analysis is to examine fetal growth patterns using longitudinal measurements throughout pregnancy of: (1) symphyseal-fundal heights; (2) weight gain at each prenatal visit; (3) serial biparietal and abdominal diameter measurements from ultrasound; and (4) maternal hemoglobin level. Regression models have been fit to the serial measurements for each mother. The coefficients of the regressions have been analyzed in relation to various indicators of birth size such as weight, crown-heel length, ponderal index, and birth weight-for-gestational age percentile. Using an analysis of covariance procedure, additional factors (e.g., cigarette smoking, alcohol intake, low maternal prepregnancy weight, etc.) will be tested for significance in modifying intrauterine growth patterns. In addition to the study described above, a prospective study to determine risk factors for intrauterine growth retardation, or small-for-gestational age birth, was begun in 1984 through the research contract mechanism with both the University of Alabama in Birmingham and University of Trondheim, Norway (in collaboration with the Universities of Bergen and Uppsala). The study protocol includes recruitment of pregnant women before 17 weeks gestation. Those enrolled in the study will be carefully monitored throughout the remainder of their pregnancy. Symmetric and asymmetric forms of intrauterine growth retardation will be assessed prenatally and at delivery. Infants born to the study mothers will have follow-up exams during the first year of life to assess catch-up growth and attainment of early developmental milestones.

该项目已扩大到包括两项相关的研究。 第一项研究分析了来自随机临床试验的数据 在怀孕期间使用超声波诊断进行的小组， 挪威特隆赫姆的挪威调查人员。分析的目的 是通过纵向测量来检查胎儿的生长模式 整个妊娠期：（1）联合体-基底高度;（2）体重增加， （3）连续测量双顶径和腹径 来自超声的测量;和（4）母体血红蛋白水平。 回归模型已拟合到每个系列测量值， 母亲对回归系数进行了分析， 出生尺寸的各种指标，例如体重，冠跟长度， 体重指数和胎龄出生体重百分位数。使用 协方差分析过程，附加因素（例如，香烟 吸烟、饮酒、孕妇孕前体重低等）将 测试在改变子宫内生长模式方面的意义。 除了上述研究外，还进行了一项前瞻性研究，以确定 胎儿宫内发育迟缓或小于胎龄儿的危险因素 1984年，通过研究合同机制， 伯明翰的亚拉巴马大学和特隆赫姆大学， 挪威（与卑尔根大学和乌普萨拉大学合作）。的 研究方案包括招募17周前的孕妇 怀孕参加研究的人将受到仔细监测 在怀孕的剩余时间里。对称和非对称 将在产前评估各种形式的宫内发育迟缓， 在交付。研究母亲所生的婴儿将接受后续检查 在生命的第一年评估追赶增长和实现 早期发展里程碑。