ANALYSIS OF SUDDEN INFANT DEATH SYNDROME (SIDS) RISK FACTORS

婴儿猝死综合症（SIDS）危险因素分析

• 批准号: 3919269
• 负责人: H J HOFFMAN
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3919269
• 关键词: cellular pathology; disease /disorder proneness /risk; electrophysiology; epidemiology; histopathology; human subject; infant mortality; information systems; postmortem; sibling order; sudden infant death syndrome; twin /multiplet

The NICHD Cooperative SIDS Study was designed to enable identification of risk factors which could differentiate SIDS infants from non-SIDS infants. The design is that of a multicent, population-based, case-control study with a sample of 838 SIDS cases (800 singleton and 38 multiple births SIDS cases) ascertained under a common necropsy protocol. There were 1,600 matched living singleton control infants and 40 co-multiple birth control infants recruited into the study. It is the largest detailed epidemiological study of SIDS ever undertaken. Data were collected for babies who died over a 15-month period from October, 1978 through December, 1979. Every infant death was autopsied in accordance with a common necropsy protocol developed specifically for the study. Twenty-six different slides of tissues were preserved for detailed examination by a panel of three SIDS pathology experts. Under an Inter Agency Agreement with the Armed Forces Institute of Pathology (AFIP), technical support is being provided for the preparation of a SIDS Histopathology Atlas and "study sets" to be used for the education of practicing forensic pathogists or pathology students. In another SIDS risk factor study, techniques of time series analysis are being used to examine potential abnormalities in the development of neurophysiological and cardio-respiratory control mechanisms in the first three months of life. The study materials consist of computerized data sets from long-term electrophysiological recordings of infants from three earlier SIDS research studies. Comparisons will be made among the following groups of infants: subsequents siblings of SIDS infants, "near- miss" infants, twins, matched controls, and infants who later died of SIDS.

NICHD合作SIDS研究旨在使 查明可区分小岛屿发展中国家的危险因素 非SIDS婴儿。 它的设计是一个多中心的， 以838例SIDS为样本的基于人群的病例对照研究 确诊婴儿猝死综合征例（单胎800例，多胎38例） 进行尸检 有1,600个匹配的 单胎对照婴儿和40例同时多胎对照婴儿 招募到研究中。 这是最大的详细 对小岛屿发展中国家进行的流行病学研究。 收集数据 从1978年10月起15个月内死亡的婴儿 直到1979年12月 每一个婴儿的死亡都是在 根据专门制定的通用尸检方案， 为了研究 26种不同的组织切片， 由三个小岛屿发展中国家组成的小组进行详细审查 病理学专家 根据与武装部队的机构间协议， 部队病理学研究所（AFIP），技术支持正在 为编制小岛屿发展中国家历史地图集提供了资金， “学习集”在法医学专业实践教学中的应用 病理学家或病理学学生。 在另一项小岛屿发展中国家风险因素研究中， 分析正在被用来检查潜在的异常， 神经生理学和心肺控制的发展 在生命的前三个月里， 研习资料 包括计算机化的数据集， 三个早期SIDS婴儿的电生理记录 调查研究。 将在以下方面进行比较 婴儿群体：小岛屿发展中国家婴儿的兄弟姐妹，“近- 错过”婴儿、双胞胎、匹配的对照组以及后来死亡的婴儿 的SIDS。