ANALYSIS OF SUDDEN INFANT DEATH SYNDROME (SIDS) RISK FACTORS

NICHD合作小岛屿发展中国家研究旨在使 可区分小岛屿发展中国家和非小岛屿发展中国家婴儿的危险因素。 设计为多中心、以人群为基础的病例对照研究 以840例小岛屿发展中国家(800例单胎和40例多胎)为样本 病例)根据共同验尸协议确定。当时有1600人 配对独生子女对照婴儿和40例共同多胎节育婴儿 被招募到研究中的婴儿。这是最大的详细信息 曾经进行过小岛屿发展中国家的流行病学研究。收集的数据用于 从1978年10月到12月的15个月内死亡的婴儿， 1979年。每一名婴儿的死亡都是根据共同的 专门为这项研究制定的尸检方案。二十六岁 保存不同的组织切片，以供详细检查 由三名小岛屿发展中国家病理专家组成的小组。根据机构间协议 与武装部队病理研究所(AFIP)合作，技术支持是 为编制小岛屿发展中国家组织病理学地图集和 “学具”在法医执业教育中的应用 病理学家或病理学专业的学生。 在另一项小岛屿发展中国家风险因素研究中，时间序列分析技术包括 被用来检查发育过程中的潜在异常 第一种神经生理和心肺控制机制 三个月的生命。研究材料由计算机化的数据组成 三岁以下婴儿长期电生理记录的集合 更早的小岛屿发展中国家研究。我们将在以下几个方面进行比较 以下婴儿组：小岛屿发展中国家婴儿的后续兄弟姐妹， “差一点”出生的婴儿、双胞胎、配对对照和后来死于 小岛屿发展中国家。

The NICHD Cooperative SIDS Study was designed to enable identification of risk factors which could differentiate SIDS infants from non-SIDS infants. The design is that of a multicenter, population-based, case-control study with a sample of 840 SIDS cases (800 singleton and 40 multiple birth SIDS cases) ascertained under a common necropsy protocol. There were 1,600 matched living singleton control infants and 40 co-multiple birth control infants recruited into the study. It is the largest detailed epidemiological study of SIDS ever undertaken. Data were collected for babies who died over a 15-month period from October, 1978 through December, 1979. Every infant death was autopsied in accordance with a common necropsy protocol developed specifically for the study. Twenty-six different slides of tissues were preserved for detailed examination by a panel of three SIDS pathology experts. Under an Inter Agency Agreement with the Armed Forces Institute of Pathology (AFIP), technical support is being provided for the preparation of a SIDS Histopathology Atlas and "study sets" to be used for the education of practicing forensic pathologists or pathology students. In another SIDS risk factor study, techniques of time series analysis are being used to examine potential abnormalities in the development of neuro-physiological and cardio-respiratory control mechanisms in the first three months of life. The study materials consist of computerized data sets from long-term electrophysiological recordngs of infants from three earlier SIDS research studies. Comparisons will be made among the following groups of infants: subsequent siblings of SIDS infants, "near-miss" infants, twins, matched controls, and infants who later died of SIDS.