IN-UTERO FETAL GROWTH PATTERNS IN RELATION TO OUTCOME AT BIRTH

这个项目已经扩大到包括两个相关的研究 学习。第一项研究分析了来自一项 诊断性超声应用的随机临床试验 挪威调查小组在#年进行的怀孕 挪威特隆赫姆。分析的目的是为了检验 使用全程纵向测量的胎儿生长模式 妊娠：(1)联合-底部高度；(2)体重增加 每次产前检查；(3)连续双顶径和腹径 超声波测量；以及(4)母体血红蛋白 水平。回归模型已适用于该系列 每一位母亲的尺寸。该模型的系数 对各种指标的回归进行了分析 出生尺寸，如体重、冠跟长度、体重指数和 出生体重对胎龄的百分位数。使用分析 协方差程序，附加因素(例如，吸烟， 酒精摄入量、孕妇孕前体重偏低等)将会是 测试了它在改变宫内生长模式方面的重要性。 除上述研究外，还有一项前瞻性研究 确定胎儿宫内发育迟缓的危险因素，或 小于胎龄儿的出生，始于1984年，通过 与宾夕法尼亚大学的研究合同机制 阿拉巴马州伯明翰分校和挪威特隆赫姆大学(In 与卑尔根大学和乌普萨拉大学的合作)。这个 研究方案包括招募17岁之前的孕妇 怀孕几周。参加这项研究的人将谨慎行事 在她们怀孕的剩余时间里一直受到监测。 对称性和非对称性宫内发育 发育迟缓将在产前和分娩时进行评估。婴儿 在这项研究中出生的母亲将在研究期间进行后续检查 人生第一年评估追赶增长和实现 早期开发里程碑。

This project has been expanded to encompass two related research studies. The first study has analyzed data derived from a randomized clinical trial of diagnostic ultrasound use during pregnancy conducted by the team of Norwegian investigators in Trondheim, Norway. The purpose of the analysis is the examine fetal growth patterns using longitudinal measurements throughout pregnancy of: (1) symphyseal-fundal heights; (2) weight gain at each prenatal visit; (3) serial biparietal and abdominal diameter measurements from ultrasound; and (4) maternal hemoglobin level. Regression models have been fit to the serial measurements for each mother. The coefficients of the regressions have been analyzed in relation to various indicators of birth size such as weight, crown-heel length, ponderal index, and birth weight-for-gestational age percentile. Using an analysis of covariance procedure, additional factors (e.g., cigarette smoking, alcohol intake, low maternal prepregnancy weight, etc.) will be tested for significance in modifying intrauterine growth patterns. In addition to the study described above, a prospective study to determine risk factors for intrauterine growth retardation, or small-for-gestational age birth, was begun in 1984 through the research contract mechanism with both the University of Alabama in Birmingham and University of Trondheim, Norway (in collaboration with the Universities of Bergen and Uppsala). The study protocol includes recruitment of pregnant women before 17 weeks gestation. Those enrolled in the study will be carefully monitored throughout the remainder of their pregnancy. Symmetric and asymmetric forms of intrauterine growth retardation will be assessed prenatally and at delivery. Infants born to the study mothers will have follow-up exams during the first year of life to assess catch-up growth and attainment of early development milestones.