IN-UTERO FETAL GROWTH PATTERNS IN RELATION TO OUTCOME AT BIRTH

与出生结果相关的宫内胎儿生长模式

• 批准号: 3942090
• 负责人: H J HOFFMAN
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942090
• 关键词: alcoholic beverage consumption; body physical characteristic; body weight; embryo /fetus monitoring; gestational age; growth /development; human birth weight; human subject; longitudinal human study; prenatal growth disorder; prenatal stress; psychobiology; statistics /biometry; ultrasonography

This project has been expanded to encompass two related research studies. The first study has analyzed data derived from a randomized clinical trial of diagnostic ultrasound use during pregnancy conducted by the team of Norwegian investigators in Trondheim, Norway. The purpose of the analysis is the examine fetal growth patterns using longitudinal measurements throughout pregnancy of: (1) symphyseal-fundal heights; (2) weight gain at each prenatal visit; (3) serial biparietal and abdominal diameter measurements from ultrasound; and (4) maternal hemoglobin level. Regression models have been fit to the serial measurements for each mother. The coefficients of the regressions have been analyzed in relation to various indicators of birth size such as weight, crown-heel length, ponderal index, and birth weight-for-gestational age percentile. Using an analysis of covariance procedure, additional factors (e.g., cigarette smoking, alcohol intake, low maternal prepregnancy weight, etc.) will be tested for significance in modifying intrauterine growth patterns. In addition to the study described above, a prospective study to determine risk factors for intrauterine growth retardation, or small-for-gestational age birth, was begun in 1984 through the research contract mechanism with both the University of Alabama in Birmingham and University of Trondheim, Norway (in collaboration with the Universities of Bergen and Uppsala). The study protocol includes recruitment of pregnant women before 17 weeks gestation. Those enrolled in the study will be carefully monitored throughout the remainder of their pregnancy. Symmetric and asymmetric forms of intrauterine growth retardation will be assessed prenatally and at delivery. Infants born to the study mothers will have follow-up exams during the first year of life to assess catch-up growth and attainment of early development milestones.

该项目已扩大到包括两个相关的研究 问题研究 第一项研究分析了来自 超声诊断在临床上的应用 挪威研究人员小组在1999年进行的一项研究中发现， 挪威，特隆赫姆。 分析的目的是检验 胎儿生长模式使用纵向测量整个 妊娠：（1）联合体-胃底高度;（2）体重增加， （3）连续测量双顶径和腹径 超声波测量;（4）母体血红蛋白 水平 回归模型已拟合到序列 为每位母亲量身定做。 的系数 回归分析已被分析的各种指标， 出生尺寸，如体重、冠踵长度、重量指数，以及 胎龄出生体重百分位数。 通过分析 协方差过程，附加因子（例如，吸烟， 酒精摄入量、孕妇孕前体重低等）将 测试在改变子宫内生长模式方面的意义。 除了上述研究外，还进行了一项前瞻性研究， 确定胎儿宫内发育迟缓的风险因素，或 小于胎龄儿出生，开始于1984年， 与两所大学的研究合同机制， 伯明翰的亚拉巴马大学和挪威的特隆赫姆大学（在 与卑尔根大学和乌普萨拉大学合作）。 的 研究方案包括招募17岁以下的孕妇 怀孕几周。 参加这项研究的人将仔细 在怀孕的剩余时间里进行监测。 子宫内生长的对称和不对称形式 将在产前和分娩时评估发育迟缓。 婴儿 研究中出生的母亲将在研究期间进行后续检查。 生命的第一年，以评估追赶增长和实现 早期发展里程碑