FREE-FATTY ACID METABOLISM AND OBESITY
FREE-FATTY ACID METABOLISM AND OBESITY
批准号:
3897732
负责人:
B V HOWARD
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
FFA周转测量结合脂质氧化率
英文摘要
FFA turnover measurements combined with lipid oxidation rate
and assessment of body composition were used to investigate
possible mechanisms of regulation of in vivo FFA metabolism and
the inter-relationships between the metabolisms of FFA,
carbohydrate, and lipoproteins. Our previous studies had shown
that FFA mobilization was less per gram of fat in obese subjects.
We also showed that a significant component of fatty acid
turnover was non-oxidative disposal. To further examine the
mechanisms of control of free-fatty acids, we have conducted
studies of free-fatty acid turnover under two metabolic
perturbations. One was the infusion of propranolol and the other
was comparing individuals on a high-saturated fat and a low-fat,
high carbohydrate diet. Propranolol infusion decreased the
turnover of free-fatty acid, and this effect was greater in more
obese individuals. During propranolol infusion, lipid oxidation was
also increased, resulting therefore in a greatly decreased
proportion of non-oxidative fatty acid disposal. During transfer
to a high saturated fat diet, fatty acid production rates also
declined and lipid oxidation increased, thus resulting in a
significantly lower proportion of non-oxidative fatty acid disposal.
The data suggest that the sympathetic nervous system plays a role
in regulating the output of fatty acids from adipose stores and
that obese individuals may differ in their sensitivity to this
regulation. Finally, the non-oxidative component of fatty acid
metabolism was lower in situations where lipid oxidation was
increased. This may reflect inhibition of triglyceride re-
esterification in sites other than adipose tissue.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
LIPOPROTEIN COMPOSITION AND METABOLISM IN PIMA INDIANS
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批准号:4690044
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
LIPOPROTEIN COMPOSITION AND METABOLISM IN PIMA INDIANS
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批准号:3964854
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
LIPID METABOLISM IN DIABETES AND THE EFFECTS OF THERAPY
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批准号:3964858
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
LIPOPROTEIN COMPOSITION AND METABOLISM IN PIMA INDIANS
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批准号:3941149
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
LIPID METABOLISM IN DIABETES AND THE EFFECTS OF THERAPY
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批准号:3941151
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
LIPID METABOLISM IN DIABETES AND THE EFFECTS OF THERAPY
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批准号:4690048
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
FREE-FATTY ACID METABOLISM AND OBESITY--IN VIVO, IN IN VITRO COMPARISONS
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批准号:3964859
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
LIPOPROTEIN COMPOSITION AND METABOLISM IN PIMA INDIANS
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批准号:3918289
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
LIPOPROTEIN METABOLISM IN DIABETES AND THE EFFECTS OF THERAPY
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批准号:3918292
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
RELATIONSHIP BETWEEN LIPID METABOLISM AND INSULIN-MEDIATED GLUCOSE DISPOSAL
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批准号:4690049
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
FREE-FATTY ACID METABOLISM AND OBESITY
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批准号:3918293
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:B V HOWARD
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依托单位:
海外基金