LIPID METABOLISM IN DIABETES AND THE EFFECTS OF THERAPY

糖尿病中的脂质代谢和治疗效果

• 批准号: 3941151
• 负责人: B V HOWARD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941151
• 关键词: apolipoproteins; blood lipoprotein metabolism; cardiovascular disorder epidemiology; dietary constituent; free fatty acids; high density lipoproteins; human subject; hypoglycemic agents; lipid metabolism; lipoprotein lipase; nutrition related tag; sulfonylurea; triglycerides; very low density lipoprotein

The increased VLDL and decreased HDL commonly associated with non-insulin dependent diabetes are of concern because of their possible role in the etiology of the greatly increased cardiovascular disease in this disorder. This study compares VLDL and LDL metabolism in non-insulin dependent diabetics and in age and weight-matched nondiabetics. Studies were conducted in diabetics before and after therapy with sulfonylureas; also diabetics were compared on high and low fat diets. The data suggest that diabetics have abnormal VLDL and that diabetes influences VLDL-TG production independent of that of apoB. LDL concentrations in diabetes are influenced by two opposing changes - increase in direct removal of VLDL, but decrease in FCR for VLDL. Improvement of glycemic control with oral hypoglycemic therapy is followed by significant falls in VLDL-TG and LDL cholesterol and reversal of abnormalities of VLDL composition, VLDL triglyceride productions, lipase activities, and HDL subfractions. Transfer of the diabetics to a high carbohydrate, low saturated fat diet is associated with decreases in LDL, no change in HDL, and no change in VLDL in most diabetics. Metabolic studies on the two diets indicate that VLDL decreases upon removal of dietary saturated fat are due to increased clearance. The larger triglyceride rich VLDL in diabetics on a low fat, high carbohydrate diet are less efficiently converted to LDL, but clearance of both VLDL apoB and VLDL triglyceride are lower. The results indicate that high carbohydrate low fat diets can result in less atherogenic lipoproteins in most subjects with non-insulin dependent diabetes.

VLDL升高和HDL降低通常与 非胰岛素依赖型糖尿病患者的问题， 它们在病因学中的可能作用大大增加 心血管疾病在这种疾病。 本研究比较 非胰岛素依赖型糖尿病患者的VLDL和LDL代谢， 在年龄和体重匹配的非糖尿病患者中。 进行研究 磺脲类药物治疗前后的糖尿病患者; 比较糖尿病患者的高脂饮食和低脂饮食。 数据 提示糖尿病患者存在异常VLDL， 影响VLDL-TG的产生，与apoB无关。 糖尿病患者的低密度脂蛋白浓度受两种相反的因素影响 变化-VLDL的直接清除增加，但 VLDL的FCR。 口服降糖药改善血糖控制 降糖治疗后VLDL-TG显著福尔斯下降 和低密度脂蛋白胆固醇和逆转异常的VLDL 组合物、VLDL甘油三酯产生、脂肪酶活性，以及 HDL亚组分。 将糖尿病患者转移到一个高 碳水化合物，低饱和脂肪饮食与减少 在LDL中，HDL没有变化，大多数人的VLDL也没有变化。 糖尿病人 对两种饮食的代谢研究表明，VLDL 去除膳食饱和脂肪后的减少是由于 提高清除率。 富含甘油三酯的VLDL在 低脂肪高碳水化合物饮食的糖尿病患者 转化为LDL，但VLDL apoB和VLDL 甘油三酯较低。 结果表明，高 碳水化合物低脂饮食可减少动脉粥样硬化 在大多数非胰岛素依赖型糖尿病患者中，