LIPID METABOLISM IN DIABETES AND THE EFFECTS OF THERAPY

糖尿病中的脂质代谢和治疗效果

• 批准号: 4690048
• 负责人: B V HOWARD
• 金额: --
• 依托单位: NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4690048
• 关键词: apolipoproteins; blood lipoprotein metabolism; cardiovascular disorder epidemiology; free fatty acids; high density lipoproteins; human subject; hypoglycemic agents; lipid metabolism; lipoprotein lipase; nutrition related tag; triglycerides; very low density lipoprotein

The increased triglyceride and decreased HDL commonly associated with diabetes are of concern because of their possible role in the etiology of the greatly increased cardiovascular disease in this disorder. Moreover, it has not been established how therapy of diabetes, especially using oral hypoglycemics, influences lipoprotein metabolism and lipase activities. This study compares VLDL metabolism, FFA metabolism and lipoprotein lipase activities in type II diabetes before and after therapy with the oral hypoglycemic agent tolinase. The results showed that improvement of glycemic control is followed by significant falls in VLDL-TG and LDL cholesterol and reversal of abnormalities of HDL subfractions. VLDL composition was abnormal in diabetics and reversed after therapy. Data on VLDL metabolism in diabetics revealed a definite clearance defect in VLDL metabolism mediated by decreases in lipoprotein lipase. The data also suggested that diabetes influences VLDL-TG production independent of that of apoB, possibly through elevations of free fatty acids.

甘油三酯升高和高密度脂蛋白降低通常与 糖尿病因其在病因学中可能发挥的作用而受到关注 这种疾病大大增加了心血管疾病的发生。 而且， 尚未确定如何治疗糖尿病，特别是使用口服药物 降血糖药，影响脂蛋白代谢和脂肪酶活性。 本研究比较了 VLDL 代谢、FFA 代谢和脂蛋白脂肪酶 II 型糖尿病口服药物治疗前后的活动 降血糖药托林酶。 结果表明，改善 血糖控制后，VLDL-TG 和 LDL 显着下降 胆固醇和 HDL 亚组分异常的逆转。 极低密度脂蛋白 糖尿病患者的成分异常，并在治疗后逆转。 数据于 糖尿病患者的 VLDL 代谢揭示了 VLDL 的明确清除缺陷 脂蛋白脂肪酶减少介导的代谢。 数据还 表明糖尿病影响 VLDL-TG 的产生，与此无关 apoB，可能是通过游离脂肪酸的升高。