LIPID METABOLISM IN DIABETES AND THE EFFECTS OF THERAPY

糖尿病中的脂质代谢和治疗效果

• 批准号: 3964858
• 负责人: B V HOWARD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3964858
• 关键词: apolipoproteins; blood lipoprotein metabolism; cardiovascular disorder epidemiology; free fatty acids; high density lipoproteins; human subject; hypoglycemic agents; lipid metabolism; lipoprotein lipase; nutrition related tag; triglycerides; very low density lipoprotein

The increased VLDL and decreased HDL commonly associated with non-insulin dependent diabetes are of concern because of their possible role in the etiology of the greatly increased cardiovascular disease in this disorder. Moreover, it has not been established how therapy of diabetes, with either diet or oral hypoglycemic agents, influences lipoprotein metabolism. This study compares VLDL and LDL metabolism, fatty acid metabolism, and lipoprotein lipase activities in type II diabetics and in age and weight-matched non-diabetics. Studies were also conducted in diabetics before and after therapy with sulfonylureas and also diabetics are being compared on high and low fat diets. The data suggest that diabetics have abnormal VLDL and that diabetes influences VLDL-TG production independent of that of apoB, possibly through elevations of free-fatty acids or glucose. LDL concentrations in diabetics are influenced by two opposing changes - increase in direct removal of VLDL, but decrease in FCR for VLDL. Improvement of glycemic control is followed by significant falls in VLDL-TG and LDL cholesterol and reversal of abnormalities of HDL subfractions and VLDL composition. Transfer to a high carbohydrate, low saturated fat diet leads to decreases in LDL and no change in HDL. This was accompanied by no change in VLDL in most diabetics; two brothers, however, showed significant increases in VLDL and glucose, indicating that diabetics must be carefully monitored when transferred to high carbohydrate regimens.

通常与非胰岛素相关的 VLDL 升高和 HDL 降低 依赖性糖尿病之所以受到关注，是因为它们可能在 这种疾病的心血管疾病发病率大大增加。 此外，尚未确定如何治疗糖尿病，无论是 饮食或口服降糖药，影响脂蛋白代谢。 这 研究比较了 VLDL 和 LDL 代谢、脂肪酸代谢和 II 型糖尿病患者的脂蛋白脂肪酶活性与年龄和年龄有关 体重匹配的非糖尿病患者。 还在糖尿病患者中进行了研究 磺脲类药物治疗前后以及糖尿病患者 比较高脂肪和低脂肪饮食。 数据显示，糖尿病患者 异常 VLDL 和糖尿病影响 VLDL-TG 产生无关 apoB 的含量，可能通过游离脂肪酸的升高或 葡萄糖。 糖尿病患者的低密度脂蛋白浓度受到两种相反的影响 变化 - VLDL 的直接去除增加，但 FCR 降低 极低密度脂蛋白。 血糖控制改善后，血糖显着下降 VLDL-TG 和 LDL 胆固醇以及 HDL 异常的逆转 亚组分和 VLDL 成分。 转为高碳水化合物、低碳水化合物 饱和脂肪饮食导致低密度脂蛋白减少，但高密度脂蛋白没有变化。 这 大多数糖尿病患者的 VLDL 没有变化；两兄弟， 然而，VLDL 和葡萄糖显着增加，表明 糖尿病患者在转入高碳水化合物饮食时必须仔细监测 治疗方案。