LIPOPROTEIN COMPOSITION AND METABOLISM IN PIMA INDIANS

皮马印第安人的脂蛋白组成和代谢

• 批准号: 3964854
• 负责人: B V HOWARD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3964854
• 关键词: Native Americans; apolipoproteins; blood lipoprotein metabolism; cardiovascular disorder epidemiology; high density lipoproteins; hormone regulation /control mechanism; human subject; insulin; low density lipoprotein; male; obesity; population genetics; radiotracer; very low density lipoprotein

Pima Indians have a high prevalence of obesity, diabetes mellitus, and hyperinsulinemia, but they have low plasma cholesterol levels, reduced low density lipoprotein (LDL) and high density lipoprotein (HDL), and decreased incidence of cardiovascular disease (CVD). Lipoprotein composition and metabolism in Pima Indians are being investigated in order to further understand control of lipoprotein metabolism and how lipoproteins are related to obesity and CVD. A multicompartmental model has been developed for the analysis of kinetic data for the simultaneous measure of VLDL, IDL, and LDL apoB metabolism. Comparsion of apoB metabolism in Pimas and weight-matched Caucasians indicated that the low LDL in Pimas is related to both higher FCR for LDL and higher proportion of VLDL metabolized without conversion to LDL. The results of lipoprotein metabolism studies suggest a large flux of substrates and regulators (e.g., insulin) which cause overproduction of lipoproteins, but that compensatory mechanisms are operative which result in maintenance of low plasma concentrations. In order to understand the reason for the lack of sex differences in HDL in the Pimas, we have studied HDL composition, lipase activities, and steroid hormone concentrations. The data indicated that obesity in this population has a stronger influence on both concentrations and composition of HDL in women. The change in HDL in obese women was associated with decreases in levels of plasma estradiol and increases in hepatic lipase activities. Since there are so few lean women in the Pima population, the net result is that HDL levels in women in the population as a whole do not differ from those of men.

皮马印第安人肥胖、糖尿病和 高胰岛素血症，但他们有低血浆胆固醇水平，降低低 高密度脂蛋白（HDL），并降低 心血管疾病（CVD）的发病率。 脂蛋白组成和 正在研究皮马印第安人的新陈代谢， 了解脂蛋白代谢的控制和脂蛋白是如何 与肥胖和心血管疾病有关 已开发了多房室模型 用于分析同时测量VLDL，IDL， 和低密度脂蛋白载脂蛋白B代谢。 Pimas和Pimas apoB代谢的比较 体重匹配的白种人表明，皮马斯的低LDL与 LDL的FCR更高，VLDL代谢的比例更高， 转化为LDL。 脂蛋白代谢研究结果表明， 底物和调节剂的大通量（例如，胰岛素），导致 脂蛋白的过度生产，但补偿机制是 有效地维持低血浆浓度。 为了了解HDL缺乏性别差异的原因， 在Pimas中，我们研究了HDL组成、脂肪酶活性和类固醇 激素浓度 数据表明，肥胖在这一人群中， 对HDL的浓度和组成有更强的影响， 妇女 肥胖妇女HDL的变化与 血浆雌二醇水平和肝脂肪酶活性增加。 由于皮马人中瘦瘦的女性很少，净结果是 女性的HDL水平与男性的HDL水平没有差异。 那些男人。