LIPOPROTEIN COMPOSITION AND METABOLISM IN PIMA INDIANS

皮马印第安人的脂蛋白组成和代谢

• 批准号: 3941149
• 负责人: B V HOWARD
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941149
• 关键词: Native Americans; apolipoproteins; blood lipoprotein metabolism; cardiovascular disorder; cardiovascular disorder epidemiology; gender difference; glucose metabolism; high density lipoproteins; hormone regulation /control mechanism; human subject; insulin; low density lipoprotein; male; obesity; population genetics; radiotracer; triglycerides; very low density lipoprotein

Lipoprotein composition and metabolism in Pima Indians are being investigated to understand control of lipoprotein metabolism and how lipoproteins are related to obesity, insulin resistance and CVD. Kinetic methods have been developed for the simultaneous study of VLDL, IDL, and LDL metabolism, for the short-term study of VLDL triglyceride metabolism, and for the in vitro evaluation of binding properties of LDL. Studies of the relationships between lipoproteins and insulin-mediated glucose disposal indicated that there is a significant positive correlation between VLDL and insulin resistance, and a significant negative correlation between HDL concentrations and insulin resistance. These correlations were stronger in men than in women and were independent of each other. When the relationships between VLDL triglyceride and VLDL apoB metabolism were examined, the data suggested that in obese subjects hyperinsulinemia or insulin resistance induces overproduction of both VLDL apoB and triglyceride, whereas in diabetes VLDL triglyceride production is stimulated through increases in plasma free fatty acids or glucose. Obesity in the Pimas had a stronger influence on HDL in women, and the changes in HDL in obese women were associated with decreases in plasma estradiol and increases in hepatic lipase activities. Our studies on HDL suggest that HDL concentrations are related to both sex hormones and also to measures of insulin resistance and that men and women may differ with respect to the relative importance of these factors.

皮马印第安人的脂蛋白组成和代谢正在被 研究以了解脂蛋白代谢的控制， 脂蛋白与肥胖、胰岛素抵抗和 CVD。 动力学方法已被开发用于同时 VLDL、IDL和LDL代谢研究，短期 VLDL甘油三酯代谢的研究，并在体外 LDL结合特性的评价。 的研究 脂蛋白和胰岛素介导的葡萄糖之间的关系 处置表明，有显着的正相关 VLDL和胰岛素抵抗之间的关系， HDL浓度与胰岛素抵抗的相关性。 这些相关性在男性中比在女性中更强， 彼此独立。 当极低密度脂蛋白 检测甘油三酯和极低密度脂蛋白载脂蛋白B代谢，数据 提示在肥胖受试者中，高胰岛素血症或胰岛素 抗性诱导VLDL apoB和 甘油三酯，而在糖尿病VLDL甘油三酯的生产是 通过血浆游离脂肪酸增加刺激，或 葡萄糖 皮马人的肥胖对高密度脂蛋白的影响更大， 肥胖妇女的HDL变化与 血浆雌二醇降低，肝脂酶升高 活动 我们对HDL的研究表明HDL浓度 与性激素和胰岛素有关 男性和女性可能在以下方面存在差异： 这些因素的相对重要性。