STUDIES ON PLATELET FACTOR VIII RELATED ANTIGEN

血小板VIII因子相关抗原的研究

• 批准号: 3939468
• 负责人: R I PARKER
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939468
• 关键词: antigens; blood coagulation; coagulation factor VIII; human tissue; immunohematology; platelet activating factor; platelet aggregation; platelets; serum globulins; von Willebrand's disease

Factor VIII-related antigen (F.VIII R:Ag) has been found on and within normal platelets. This pool of F.VIII R:Ag is intrinsic to the platelet and non-exchangable with circulating plasma F.VIII R:Ag. Any interaction of this platelet F.VIII R:Ag with plasma coagulation factors is merely speculative at this time. This project seeks to quantitate the amount of F.VIII R:Ag located on/within the platelet and identify the site(s) at which it is located and any role it may play during platelet activation and plasma coagulation activation. In addition, by using this system of anti-F.VIII R:Ag/F.VIII R:Ag as a probe/marker, we hope to clarify the many processes involved in platelet activation and better understand the energy-dependent nature of these processes.

因子VIII相关抗原（F.VIII R：Ag）已在 正常血小板内。 这种F.VIII R：Ag池是 血小板不能与循环血浆交换F.VIII R：Ag。 该血小板F.VIII R：Ag与血浆的任何相互作用 凝血因子目前还只是推测性的。 这 该项目旨在量化F.VIII R：Ag的数量， 血小板上/内，并确定其所在部位 以及它在血小板活化过程中可能发挥的任何作用， 血浆凝固激活。 此外，通过使用该系统， 抗F.VIII R：Ag/F.VIII R：Ag作为探针/标记物，我们希望 阐明血小板活化中涉及的许多过程， 更好地理解这些能源依赖的性质 流程.