PLATELET FACTOR VIII RELATED ANTIGEN

血小板因子 VIII 相关抗原

• 批准号: 3916513
• 负责人: R I PARKER
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916513
• 关键词: antigens; bioenergetics; coagulation factor VIII; human tissue; immunohematology; platelet activation; platelet aggregation; serum globulins; von Willebrand's disease

Factor VIII-related antigen (F.VIII R:Ag) has been found on and within normal platelets. This pool of F.VIII R:Ag is intrinsic to the platelet and non-exchangeable with circulating plasma F.VIII R:Ag. Any interaction of this platelet F.VIII R:Ag with plasma coagulation factors is merely speculative at this time. This project seeks to quantitate the amount of F.VIII R:Ag located on/within the platelet and identify the site(s) at which it is located and any role it may play during platelet activation and plasma coagulation activation. In addition, by using this system of anti-F.VIII R:Ag/F.VIII R:Ag as a probe/marker, we hope to clarify the many processes involved in platelet activation and better understand the energy-dependent nature of these processes.

已在 和 上发现因子 VIII 相关抗原 (F.VIII R:Ag) 正常血小板内。 F.VIII R:Ag 池是固有的 血小板不可与循环血浆交换 F.VIII 抹布。 该血小板 F.VIII R:Ag 与血浆的任何相互作用 凝血因子目前还只是推测。 这 项目旨在定量 F.VIII R:Ag 的含量 血小板上/内并识别其所在的位点 其在血小板活化过程中的定位及其可能发挥的作用 血浆凝固激活。 此外，通过使用该系统 抗 F.VIII R:Ag/F.VIII R:Ag 作为探针/标记物，我们希望 阐明血小板活化所涉及的许多过程， 更好地了解这些过程的能量依赖性。