PLATELET-VON WILLEBRAND FACTOR VIII RELATED ANTIGEN

血管性血友病因子（vWf;因子VIII相关抗原，R：Ag）已被广泛应用于临床。 在正常血小板上和血小板内发现。这个血小板-vWf池是 是血小板固有的，不可与循环血浆vWf交换。 这种血小板-vWf与血浆凝血因子的任何相互作用都是 目前只是推测，因为它在血小板中所起的作用 介导初次止血。该项目旨在量化 位于血小板上/内的血小板-vWf。此外，研究将 试图确定血小板-vWf在血小板活化中起什么作用， 主要止血和血浆凝固。通过使用该系统， 鉴定血小板表面的血小板vWf，我们希望能够 识别循环中的“活化”血小板，并更好地了解 血小板被激活的过程的本质。

Von Willebrand factor (vWf; Factor VIII-related antigen, R:Ag) has been found on and within normal platelets. This pool of platelet-vWf is intrinsic to the platelet and non-exchangeable with circulating plasma vWf. Any interaction of this platelet-vWf with plasma coagulation factors is merely speculative at this time as is the role it plays in platelet mediated primary hemostasis. This project seeks to quantitate the amount of platelet-vWf located on/within the platelet. Additionally, the studies will attempt to determine what role platelet-vWf plays in platelet activation, primary hemostasis, and plasma coagulation. By using this system to identify platelet-vWf on the surface of platelets, we hope to be able to identify circulating "activated" platelets and to better understand the nature of the processes by which platelets become activated.