PLATELET-VON WILLEBRAND FACTOR VIII RELATED ANTIGEN

血小板血管性血友病因子 VIII 相关抗原

• 批准号: 3874339
• 负责人: R I PARKER
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874339
• 关键词: antigens; coagulation factor VIII; hemostasis; human tissue; immunohematology; plasma; platelet activation; platelet aggregation; von Willebrand factor; von Willebrand's disease

Von Willebrand factor (vWf; Factor VIII-related antigen, R:Ag) has been found on and within normal platelets. This pool of platelet-vWf is intrinsic to the platelet and non-exchangeable with circulating plasma vWf. Any interaction of this platelet-vWf with plasma coagulation factors is merely speculative at this time as is the role it plays in platelet mediated primary hemostasis. This project seeks to quantitate the amount of platelet-vWf located on/within the platelet. Additionally, the studies will attempt to determine what role platelet-vWf plays in platelet activation, primary hemostasis, and plasma coagulation. By using this system to identify platelet-vWf on the surface of platelets, we hope to be able to identify circulating "activated" platelets and to better understand the nature of the processes by which platelets become activated.

血管性血友病因子(vWF；因子VIII相关抗原，R：Ag) 在正常的血小板上和体内发现。这一池的血小板-vwf是 是血小板固有的，不能与循环血浆VWF交换。 这种血小板-VWF与血浆凝血因子的任何相互作用 目前只是推测，因为它在血小板中所起的作用 中介一次止血。这个项目试图量化 血小板-VWF位于血小板上/内。此外，这些研究将 试图确定血小板-VWF在血小板激活中起什么作用， 一次止血和血浆凝固。通过使用该系统来 鉴定血小板表面的VWF，我们希望能够 识别循环中的“激活”的血小板并更好地了解 血小板激活的过程的本质。