STUDIES ON PLATELET FACTOR VIII RELATED ANTIGEN

血小板VIII因子相关抗原的研究

• 批准号: 4692036
• 负责人: R I PARKER
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692036
• 关键词: antibody formation; antigens; blood coagulation; coagulation factor VIII; immunohematology; platelet activating factor; platelet aggregation; serum globulins; von Willebrand's disease

Factor VIII-related antigen (F.VIII R:Ag) has been found on and within normal platelets. This pool of F.VIII R:Ag is felt to be intrinsic to the platelet and non-exchangeable with circulating plasma F.VIII R:Ag. Any interaction of this platelet F.VIII R:Ag with plasma coagulation factors is merely speculative at this time. This project seeks to quantitate the amount of F.VIII R:Ag located on/within the platelet and identify the site(s) at which it is located and any role it may play during platelet activation and plasma coagulation activation. In addition, by using this system of anti-F.VIII R:Ag/F.VIII R:Ag as a probe/marker, we hope to clarify the many processes involved in platelet activation and better understand the energy-dependent nature of these processes.

第VIII因子相关抗原(F.VIII R：Ag)已在其表面和内部被发现 正常的血小板。这个F.VIII R：Ag池被认为是 血小板，不能与循环血浆F·VIII R：Ag交换。任何 此血小板F.VIII R：Ag与血浆凝血因子相互作用 在这个时候仅仅是推测。这个项目试图量化 位于血小板上/内的F.VIII R：Ag的量，并鉴定 它所在的部位(S)以及它在血小板形成过程中可能发挥的作用 激活和血浆凝固激活。此外，通过使用这个 抗F.VIII R：Ag/F.VIII R：Ag系统作为探针/标志物，我们希望 阐明参与血小板活化的许多过程，并更好地 理解这些过程对能源的依赖性。