STUDIES ON PLATELET FACTOR VIII RELATED ANTIGEN

已发现凝血因子VIII相关抗原（F.VIII R：Ag） 正常血小板 这种F.VIII R：Ag池被认为是本征的。 血小板和不可交换的循环血浆F.VIII R：Ag。 任何 这种血小板F.VIII R：Ag与血浆凝血因子相互作用， 只是推测而已 该项目旨在量化 位于血小板上/内的F.VIII R：Ag的量，并鉴定 它所处的部位及其在血小板聚集过程中可能发挥的任何作用 激活和血浆凝固激活。 此外，通过使用此 抗F.VIII R：Ag/F.VIII R：Ag系统作为探针/标记物，我们希望 阐明血小板活化中涉及的许多过程， 了解这些过程的能量依赖性。

Factor VIII-related antigen (F.VIII R:Ag) has been found on and within normal platelets. This pool of F.VIII R:Ag is felt to be intrinsic to the platelet and non-exchangeable with circulating plasma F.VIII R:Ag. Any interaction of this platelet F.VIII R:Ag with plasma coagulation factors is merely speculative at this time. This project seeks to quantitate the amount of F.VIII R:Ag located on/within the platelet and identify the site(s) at which it is located and any role it may play during platelet activation and plasma coagulation activation. In addition, by using this system of anti-F.VIII R:Ag/F.VIII R:Ag as a probe/marker, we hope to clarify the many processes involved in platelet activation and better understand the energy-dependent nature of these processes.